Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles (steviagly)
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|ClinicalTrials.gov Identifier: NCT02146183|
Recruitment Status : Unknown
Verified May 2014 by Per Bendix Jeppesen, Aarhus University Hospital.
Recruitment status was: Recruiting
First Posted : May 23, 2014
Last Update Posted : May 23, 2014
|Condition or disease||Intervention/treatment||Phase|
|Glycogen Depletion||Dietary Supplement: Carbohydrate steviol glycosides Dietary Supplement: Placebo Corn Starch||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Compositions Comprising a Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles|
|Study Start Date :||September 2013|
|Estimated Primary Completion Date :||February 2015|
|Estimated Study Completion Date :||July 2015|
Placebo Comparator: placebo / Corn starch
Carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. This composition will be 500 mg placebo starch corn.
Dietary Supplement: Placebo Corn Starch
Active Comparator: Carbohydrate steviol glycosides
500 mg steviol glycosides.
Dietary Supplement: Carbohydrate steviol glycosides
To investigate if intake of stevioside in addition to a carbohydrate-containing composition after work related depletion of muscle glycogen will increase the rate of glycogen re-synthesis as compared with intake of the carbohydrate-containing composition alone.
- Effects on glycogen re-synthesis [ Time Frame: 2 weeks ]
During the working session the test subjects will be exercising for 2 hours on a bicycle ergometer at 65-75% of VO2-max.
Immediately after the working session the test subject will be given a carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. Also 2 hours after completion of the working session the test persons will be given a carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. These compositions will be added either 500 mg stevioside or placebo (starch corn).
After collection of the muscle biopsies the samples will be stored under liquid nitrogen. The parameter evaluated in the muscles biopsies will be glycogen.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02146183
|Contact: Per B Jeppesen, prof, PhDfirstname.lastname@example.org|
|Aarhus University Hospital, Dept of Clinical medicine||Recruiting|
|Aarhus C, Denmark, 8000|
|Contact: Per B Jeppesen, Prof, PhD +45-28151877 email@example.com|
|Principal Investigator: Per B Jeppesen, Prof, PhD|
|Sub-Investigator: Søren Larvsen, Prof-Sport|
|Principal Investigator:||Per B Jeppesen, Prof., PhD||Aarhus University Hospital|