The Effects of Lifting Light or Heavy Weights on Muscle Growth and Strength in Trained Young Men
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|ClinicalTrials.gov Identifier: NCT02139865|
Recruitment Status : Completed
First Posted : May 15, 2014
Last Update Posted : March 19, 2018
When practicing weightlifting regularly the body makes new proteins within the muscle.
These new proteins can increase the size of the cells within the muscle to make them larger, a process called hypertrophy. The common convention surrounding gains in skeletal muscle size and strength is that heavy weights are needed. In contrast, lifting lighter weights are thought to be required to induce muscular endurance and not to promote growth. However, it has previously been shown in untrained men that lifting lighter weights results in similar gains in muscle mass and strength as lifting heavier weights. The purpose of this study is to examine how performing resistance training of different intensities (light or heavy weights) affects the degree of muscle growth and strength gain in individuals who are already resistance training.
This information will be valuable when designing exercise protocols for increasing muscle size and strength at all ages, or in individuals returning from injury, as a way to stimulate muscle growth and promote strength gains without the need to lift heavy weights.
|Condition or disease||Intervention/treatment||Phase|
|Skeletal Muscle Hypertrophy Muscle Weakness||Behavioral: 30% 1RM Behavioral: 80% 1RM||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effects of Resistance Training Intensity on Muscular Hypertrophy and Strength in Young, Resistance Trained Men|
|Study Start Date :||May 2014|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||March 2016|
Training at 30% 1RM
Behavioral: 30% 1RM
Participant exercises using a protocol tailored at 30% of their 1RM
Training at 80% 1RM
Behavioral: 80% 1RM
Participant exercises using a protocol tailored at 80% of their 1RM
- Muscle Volume [ Time Frame: 0 weeks (baseline) and 12 weeks ]Change from baseline at 12 weeks Measured via 4 compartment model
- Gene expression [ Time Frame: 0 weeks (baseline) and 12 weeks ]Change from baseline at 12 weeks . Gene expression for proteins involved in muscle protein synthesis measured from muscle biopsy.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02139865
|Exercise Metabolism Research Laboratory, McMaster Univeristy|
|Hamilton, Ontario, Canada, L8S 4K1|
|Hamilton, Ontario, Canada, L8S 4L8|
|Principal Investigator:||Stuart Phillips, Ph.D.||McMaster University|