Working… Menu

Assessment of Neuropathic Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02138344
Recruitment Status : Recruiting
First Posted : May 14, 2014
Last Update Posted : July 16, 2020
Information provided by (Responsible Party):
University of Zurich

Brief Summary:
Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases. The functionality of the pain pathway in humans as well as its plastic changes following SCI can be assessed in vivo by surface electrophysiological recordings and functional magnetic resonance imaging after noxious heat stimulation of the skin. Aims: a) establishing a clinically applicable assessment of the pain pathway and characterizing its changes as a consequence of SCI and in peripheral nerve diseases in an objective manner, b) characterizing plastic changes in the pain pathway in SCI patients with neuropathic pain and in patients with peripheral nerve diseases and relating them to the development of neuropathic pain syndromes.

Condition or disease
Spinal Cord Injury + Peripheral Nerve Diseases

Layout table for study information
Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case-Control
Time Perspective: Prospective
Study Start Date : April 2006
Estimated Primary Completion Date : December 2024
Estimated Study Completion Date : December 2024

Resource links provided by the National Library of Medicine

SCI subjects
Chronic and traumatic SCI subjects
Healthy control subjects
Subjects with peripheral nerve diseases

Primary Outcome Measures :
  1. Pain, sensory and autonomic assessments [ Time Frame: 2 - 4 weeks ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects with SCI and peripheral nerve diseases

Inclusion Criteria:

  • Uninjured
  • Scord injured subjects
  • Subjects with peripheral nerve diseases

Exclusion Criteria:

  • Presence of any central psychiatric disorder (that precludes subject from giving informed and voluntary consent)
  • For fMRI measurements: "yes" for any item in the MR-risk questionnaire

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02138344

Layout table for location contacts
Contact: Michèle Hubli +41 44 510 72 03

Layout table for location information
Curt, Armin, MD Recruiting
Zurich, Switzerland, 8008
Sponsors and Collaborators
University of Zurich
Layout table for additonal information
Responsible Party: University of Zurich Identifier: NCT02138344    
Other Study ID Numbers: EK-04/2006 / PB_2016-02051
First Posted: May 14, 2014    Key Record Dates
Last Update Posted: July 16, 2020
Last Verified: July 2020
Additional relevant MeSH terms:
Layout table for MeSH terms
Spinal Cord Injuries
Nervous System Diseases
Peripheral Nervous System Diseases
Spinal Cord Diseases
Central Nervous System Diseases
Trauma, Nervous System
Wounds and Injuries
Neuromuscular Diseases