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Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients (PRD-MI)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2014 by
Recruitment status was:  Recruiting
Information provided by (Responsible Party): Identifier:
First received: February 5, 2014
Last updated: April 29, 2014
Last verified: April 2014
Increased periodic repolarization dynamics (PRD) indicate increased risk of death in cardiac patients. This study thoughts to prospectively validate the prognostic value of PRD in post-infarction patients.

Myocardial Infarction

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients: Validation Study

Resource links provided by NLM:

Further study details as provided by

Primary Outcome Measures:
  • Number of total deaths [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Number of cardiovascular deaths [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 800
Study Start Date: October 2010
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Detailed Description:

Periodic repolarization dynamics (PRD) reflect periodic changes of repolarization instability located in the low-frequency spectral range. Level of PRD can be assessed using a high resolution surface ECG recorded in the 12-leads of Frank leads configuration during resting conditions.

Increased levels of PRD have been associated with sympathetic overactivity and increased risk of mortality in survivors of acute myocardial infarction and patients undergoing a clinically indicated exercise test.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
myocardial infarction

Inclusion Criteria:

  • previous myocardial infarction >4 weeks
  • age >18 years

Exclusion Criteria:

  • life expectancy < 1 year due to non-cardiac causes
  • unable to give informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT02128477

Eberhard-Karls-University Tuebingen
Tuebingen, Baden-Württemberg, Germany, 72076
Sponsors and Collaborators
  More Information

Responsible Party: Identifier: NCT02128477     History of Changes
Other Study ID Numbers: BIO012014 
Study First Received: February 5, 2014
Last Updated: April 29, 2014
Health Authority: Germany: Ethics Commission

Keywords provided by
Myocardial infarction
Repolarization instability
Ventricular fibrillation

Additional relevant MeSH terms:
Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases processed this record on December 09, 2016