Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men
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|ClinicalTrials.gov Identifier: NCT02127346|
Recruitment Status : Completed
First Posted : April 30, 2014
Last Update Posted : October 5, 2015
|Condition or disease|
Periodontal disease including chronic periodontitis results from interaction between pathogens and the host inﬂammatory response. This interaction triggers a complex process of inﬂammatory events, which in turn promote connective tissue destruction and alveolar bone remodeling. Periodontitis is described as a multifactorial irreversible and cumulative condition, initiated and propagated by bacteria and host factors.
Vitamin D and calcium are fundamental for bone mineralization and for the prevention of osteoporosis Severe vitamin D deficiency lead to mineralization defects but chronically low intake of vitamin D and calcium leads to bade calcium balance and bone loss, and it is reasonable to expect this effect to occur in alveolar bone as it does in other bones of the body. A study has showed a positive association between low bone mass or osteoporosis and alveolar bone loss and tooth loss.
Vitamin D serum concentrations might affect periodontal disease both through an effect on bone mineral density (BMD) and through immunomodulatory effects. Vitamin D is well established as being essential for bone growth and preservation. A potential anti-inflammatory effect of vitamin D is supported by an increasing amount of literature. The active metabolite of 25-hydroxyvitamin D, 1,25dihydroxyvitamin D, has been found to inhibit cytokine production and cell proliferation.
Low serum levels of vitamin D have been linked with a loss of periodontal attachment. Data from over 11,000 subjects were analyzed for serum vitamin D levels and attachment loss. In subjects less than 50 years of age, there was no signiﬁcant association reported between vitamin D levels and attachment loss. In patients 50 years or older, serum vitamin D levels were inversely associated with attachment loss for men and women. It was concluded that the increased risk for periodontal disease might be attributable to low levels of vitamin D, which would reduce bone mineral density, or to an immunomodulatory eﬀect.
In van der Putten et al study, based on the literature available to date, the association of vitamin D, and calcium deﬁciencies with periodontal disease in elderly people is essentially still unknown and not well researched. To produce conclusive evidence on the subject of this systematic literature review, longitudinal cohort studies and follow-up randomized controlled trials are needed
The aim of this study is to explore chronic periodontitis status and serum vitamin D and calcium concentrations in Syrian males and compare these figures with matched healthy volunteers with no periodontitis.
|Study Type :||Observational|
|Actual Enrollment :||200 participants|
|Observational Model:||Case Control|
|Official Title:||Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men|
|Study Start Date :||May 2014|
|Actual Primary Completion Date :||August 2015|
|Actual Study Completion Date :||October 2015|
- Serum Vitamin D concentration [ Time Frame: One time assessment, within 24 hours before delivering any treatment ]
- Serum Calcium concentration [ Time Frame: One time assessment, within 24 hours before delivering any treatment ]
- Pocket Depth [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]
- Bleeding on Probing [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]
- Clinical Attachment Loss (CAL) [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02127346
|Syrian Arab Republic|
|Department of Periodontics, University of Damascus Dental School|
|Damascus, Syrian Arab Republic, DM20AM18|
|Principal Investigator:||Mohammad Alharissi, DDS MSc||PhD student, Department of Periodontics, University of Damascus Dental School, Damascus|
|Study Chair:||Suleiman Dayoub, DDS MSc PhD||Associate Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus|
|Study Director:||Rowaida Saymeh, DDS MSc PhD||Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus|