We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

United Coronary Biobanks (UNICORN)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02126150
Recruitment Status : Completed
First Posted : April 29, 2014
Last Update Posted : December 8, 2015
National University Hospital, Singapore
Information provided by (Responsible Party):
Crystel Gijsberts, UMC Utrecht

Brief Summary:

The UNICORN consists of two collaborating biobanks, one in Utrecht and one in Singapore. From these two sites we include all patients who undergo a coronary catheterization for any reason.

At the moment of catheterization we draw blood, which will be stored in a biobank and we collect clinical characteristics. Patients are followed-up for 5 years for the occurrence of major cardiovascular events.

By including from two sites in the world we include 4 major ethnic groups: Caucasians, Chinese, Indians and Malays. We aim at including at least 2000 patients per ethnic group.

Our hypothesis is that there are differences in the risk factor burden, clinical presentation of CAD, and biochemical patterns in the blood among the ethnic groups.

Furthermore, this biobank offers a platform for multi-ethnic biomarker discovery.

Condition or disease
Coronary Artery Disease Acute Coronary Syndrome Myocardial Infarction Stable Angina

Study Type : Observational
Actual Enrollment : 2000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: United CORoNary Biobanks
Study Start Date : September 2010
Primary Completion Date : December 2015
Study Completion Date : December 2015


Primary Outcome Measures :
  1. All-cause death [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. Major cardiovascular events [ Time Frame: 5 years ]

Biospecimen Retention:   Samples With DNA
Plasma, peripheral blood mononuclear cells and whole blood is stored.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients that undergo coronary catheterization for any reason are eligible to enroll in the study.

Inclusion Criteria:

  • Patients undergoing coronary angiography

Exclusion Criteria:

  • < 21 years of age
  • Hemoglobin levels <7 g/dL in women, or hemoglobin levels <8 g/dL in men

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02126150

National University Hospital
Singapore, Singapore, 119074
Sponsors and Collaborators
UMC Utrecht
National University Hospital, Singapore

Responsible Party: Crystel Gijsberts, MD, UMC Utrecht
ClinicalTrials.gov Identifier: NCT02126150     History of Changes
Other Study ID Numbers: 11-183
First Posted: April 29, 2014    Key Record Dates
Last Update Posted: December 8, 2015
Last Verified: December 2015

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Myocardial Infarction
Acute Coronary Syndrome
Angina, Stable
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Angina Pectoris
Chest Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms