The Genetic Basis of Acquired Heart Disease in Africa
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|ClinicalTrials.gov Identifier: NCT02124109|
Recruitment Status : Completed
First Posted : April 28, 2014
Last Update Posted : March 12, 2019
- An acquired heart disease is one that a person gets after they are born. Two of these are rheumatic heart disease (RHD) and endomyocardial fibrosis (EMF). They are found more commonly in people who live in Africa than in other places in the world. Researchers want to learn more about these diseases. They especially want to know what role genes and other factors play in them.
- To identify genetic risk factors for RHD and EMF in sub-Saharan Africa.
- Children and adults with RHD or EMF.
- Healthy volunteers over age 10.
- Participants will come from existing study groups in Uganda and Nigeria.
- Participants may be required to provide a sample of their DNA. They will do this with either a blood or saliva sample or a swab of the mouth.
- Collected samples will be labeled with a code and sent to a lab in the United States for analysis. Remaining portions of participants samples will be stored for an unlimited period of time. They may be used in future studies.
- Some genetic and health information from participants might be placed into one or more scientific databases.
- Participant names and identifying information will be kept private. But there is a small chance someone could trace them from their genetic information.
|Condition or disease|
|Rheumatic Heart Disease Rheumatic Fever Endomyocardial Fibrosis Acquired Heart Disease|
|Study Type :||Observational|
|Actual Enrollment :||736 participants|
|Official Title:||The Genetic Basis of Acquired Heart Disease in Africa|
|Actual Study Start Date :||April 3, 2014|
|Actual Primary Completion Date :||March 8, 2019|
|Actual Study Completion Date :||March 8, 2019|
rheumatic heart disease
Patients with rheumatic heart disease
- Extension of study [ Time Frame: ongoing ]Extend our previous epidemiological studies of RHD in Ugandan schoolchildren (Beaton et al 2012) by conducting a similar study ofRHD in Nigerian children
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02124109
|University of Lagos|
|Principal Investigator:||Maximilian Muenke, M.D.||National Human Genome Research Institute (NHGRI)|