Comparison of Two Kinds of Postoperative Analgesia After Amputation
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ClinicalTrials.gov Identifier: NCT02114463 |
Recruitment Status : Unknown
Verified March 2015 by bo xu, Guangzhou General Hospital of Guangzhou Military Command.
Recruitment status was: Recruiting
First Posted : April 15, 2014
Last Update Posted : March 12, 2015
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Condition or disease | Intervention/treatment | Phase |
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Pain Complications | Procedure: Local analgesic Procedure: Intravenous analgesic Drug: ropivacaine Drug: flurbiprofen | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 36 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial |
Study Start Date : | March 2014 |
Estimated Primary Completion Date : | August 2016 |
Estimated Study Completion Date : | August 2016 |

Arm | Intervention/treatment |
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Experimental: Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
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Procedure: Local analgesic
Patient will be performed under combined lumbar plexus and sciatic nerve block with 0.33% ropivacaine.At the end of surgery,two catheters are left in the wound.One is intraarticular and the other is on the surface of articular cavity.And then a pump elastomeric infusion pump will be connected with the catheters, which runs 5mL every hours. Drug: ropivacaine 0.2% ropivacaine |
Active Comparator: Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
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Procedure: Intravenous analgesic
People in this group will also receive an anesthesia of combined lumbar plexus and sciatic nerve block with 0.33% ropivacaine.An intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg will will provide postoperative pain management.The patients will received a 2 mL/h continuous basal infusion and 1 mL boluses with a lockout time of 30 min after a 5 mL Loading dose at the end of the surgery. Drug: flurbiprofen flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg |
- pain [ Time Frame: 72 hours postoperation ]Up to 72 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain.
- Phantom pain [ Time Frame: three months postoperation ]Investigators asked the patient wether there is phantom pain at three months after surgery
- complication [ Time Frame: 72 hours postoperation ]Investigators document the incidence of nausea,vomiting,headache,urinary retention and et al

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Patients of American Association of anesthetists(ASA)Grade 1 or 2
- Aged between 18 and 65 years
- Undergoing elective total knee replacement
Exclusion Criteria:
- Mental illness can not match
- Nerve block, epidural anesthesia contraindicated
- People who have Slow-type arrhythmias
- History of chronic headaches and long-term use of analgesic drugs
- People who were postoperative consciousness, language or hearing impaired

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02114463
Contact: bo xu, associate chief physician | 88653387 ext 020 | xubo333@hotmail.com |
China, Guangdong | |
Guangzhou Military Region General Hospital, Department of Anesthesiology | Recruiting |
Guangzhou, Guangdong, China, 510010 | |
Contact: Dong Xu Zhou 13268260337 ext 86 13268260337@163.com |
Responsible Party: | bo xu, associate chief physician, Guangzhou General Hospital of Guangzhou Military Command |
ClinicalTrials.gov Identifier: | NCT02114463 |
Other Study ID Numbers: |
Phantom limb pain |
First Posted: | April 15, 2014 Key Record Dates |
Last Update Posted: | March 12, 2015 |
Last Verified: | March 2015 |
Local analgesia system Ropivacaine Analgesic efficacy after operation Postoperative |
Flurbiprofen Analgesics Ropivacaine Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents |
Peripheral Nervous System Agents Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |