Triglyceride/High-density Lipoprotein Cholesterol Ratio in Chronic Kidney Disease
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|ClinicalTrials.gov Identifier: NCT02113462|
Recruitment Status : Completed
First Posted : April 14, 2014
Last Update Posted : April 14, 2014
|Condition or disease|
|Chronic Kidney Disease|
Cardiovascular disease (CVD) risk is substantially increased in subjects with chronic kidney disease (CKD).The reasons for the elevated risk of CVD in patients with CKD are not fully elucidated. There is not a good prognostic tool for the prediction of increased cardiovascular risk in CKD. A simple, widely available, relatively inexpensive, and generally reproducible marker to predict the CVD risk in subjects with CKD is needed.
The Triglycerides (TG) to High Density Lipoprotein Cholesterol (HDL-C) ratio is a feature of insulin resistance and an independent predictor of cardiovascular risk. No study has been performed so far, to evaluate the role of TG/HDL ratio to predict the CVD risk in patients with CKD.
This study is designed to evaluate the relationship between TG/HDL-C ratio and the endothelial functions in patients with CKD.
|Study Type :||Observational|
|Actual Enrollment :||197 participants|
|Official Title:||The Prospective Cohort Study to Investigate the Role of Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio To Predict Cardiovascular Outcomes in Chronic Kidney Disease.|
|Study Start Date :||January 2009|
|Actual Primary Completion Date :||January 2013|
|Actual Study Completion Date :||January 2013|
- All cause mortality [ Time Frame: 30 months ]The COX analysis was performed in order to establish which covariates were independent predictors of cardiovascular outcomes. Kaplan Meier survival curves are generated to show the impact of the TG/HDL ratio on the cumulative survival of the cohort. The predictive power of the median TG/HDL ratio in each CKD stage for all-cause mortality and cardiovascular events are measured.
- Endothelial functions assessed by flow mediated dilatation and serum ADMA measurement [ Time Frame: Once in recruitment ]The predictive role of TG/HDL ratio on endothelial functions (ADMA and flow mediated dilatation) is determined by univariate and multivariate analyses.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02113462
|Gulhane School of Medicine Department of Endocrinology and Metabolism|
|Ankara, Turkey, 06018|