The Effect of Neurodynamic Mobilization Exercise on Lower Limb Pain in Patients With Rheumatoid Arthritis.
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02110940|
Recruitment Status : Unknown
Verified February 2016 by LO CHI NGAI, The Hong Kong Polytechnic University.
Recruitment status was: Recruiting
First Posted : April 10, 2014
Last Update Posted : February 25, 2016
|Condition or disease||Intervention/treatment||Phase|
|Rheumatoid Arthritis||Other: Neurodynamic mobilization exercise Other: Conservative Physiotherapy||Not Applicable|
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by generalized joints inflammation. With increasing investigation on the pathology, the treatment focus on the conditions shifted from a musculoskeletal point of view to a systemic approach. The awareness of holistic treatment was also increased.
Latest studies have found out the neurogenic inflammatory mechanism played an important role in the inflammatory process of RA, the pathological changes of neural tissues in RA were also noted.
This clinical trial is the first study to apply neurodynamic mobilization, a nervous system specific therapeutic exercise, on patients with RA. Objective of the study is to find out the effect of neurodynamic mobilization for joint inflammation in patients with RA.
Population Adults who are diagnosed with Rheumatoid Arthritis.
Intervention Neurodynamic Exercise
Comparison Standard conservative physiotherapy protocol
Outcome Rheumatoid Arthritis Pain Scale (RAPS) C-reactive protein (CRP) test
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||The Effect of Neural Mobilization Exercise on Lower Limb Pain in Patients With Rheumatoid Arthritis.|
|Study Start Date :||August 2015|
|Estimated Primary Completion Date :||August 2016|
|Estimated Study Completion Date :||August 2016|
Active Comparator: Conservative Physiotherapy
Subjects will be referred to the physiotherapy department to receive conventional physiotherapy treatment.
Other: Conservative Physiotherapy
The control group is assigned to received conventional treatment in the physiotherapy department with the standard rehabilitation protocol consisted of electrotherapy for pain relief, strengthening exercise to increase the strength of the thigh
Experimental: Neurodynamic mobilization exercise
The experimental group will be given three neurodynamic mobilization exercises which focus more on lower limbs and the major innervating cutaneous nerves - saphenous nerve, sciatica nerve and femoral nerve.
Subjects will be instructed to practice everyday, each action repeat for 10 times.
Other: Neurodynamic mobilization exercise
The mobilization exercise is conducted with 10 repetitions for each action, the action is hold for 5 seconds when subjects had the stretch feeling. The series of exercise is told to perform 2 sets a day, daily practice.
Subjects' conditions will be reviewed at the end of 4th and 8th week. An exercise log book will be provided for each subject to record down the compliance of the exercise.
- Rheumatoid Arthritis Pain Scale (RAPS) [ Time Frame: 8 weeks ]
Rheumatoid Arthritis Pain Scale (RAPS) will be used to rate the severity of the pain in subjects with RA; before, between and after the experimental period. The questionnaire consists of 24 items with a scale from 0-6 to quantify the severity of the Rheumatoid Arthritis
The test will be conducted in the baseline, at 4th week, and the end of the investigation at 8th week.
- C-reactive protein (CRP) test [ Time Frame: 8 weeks ]
C-reactive protein (CRP) is one of the most widely used measurements to indicate the severity of inflammation in rheumatoid arthritis. The choice of CRP is due to its cost effectiveness, reliability and reproducibility.
The test will be coducted by nurses, a 3cc blood sample will be taken from the subject and sent to the laboratory to investigate the C-reactive protein level. The test will be conducted in the baseline, at 4th week, and the end of the investigation at 8th week.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02110940
|Contact: Chi ngai Lo, Master||+852 2766 email@example.com|
|Contact: Xia Guo, MD, PhD||+852 2766 6720||Xia.Guo@polyu.edu.hk|
|The Hong Kong Polytechnic University||Recruiting|
|Hong Kong, Hong Kong|
|Contact: Chi ngai Lo, Master +852 2766 6752 firstname.lastname@example.org|
|Principal Investigator: Chi ngai Lo, Master|
|Principal Investigator:||Chi Ngai Lo, Master|