Observational Study of Corneal Opacities in Adults
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A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.
Identification of suitable subjects [ Time Frame: 2 years ]
The primary goal of this observational study is to identify suitable subjects for the clinical trials of OCT-guided transepithelial PTK.
Secondary Outcome Measures :
Validate OCT topography [ Time Frame: 2 years ]
A second goal is to validate OCT anterior topography by comparison with standard Placido-ring corneal topography and develop a mathematical model that relates epithelial thickness variation to corneal mean curvature.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 100 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy)
• Adult (18 & older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy)
Inability to give informed consent.
Inability to maintain stable fixation for OCT imaging.
Inability to commit to required visits to complete the study.