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Trial record 44 of 3313 for:    schizophrenia

Retrieval Practice and Schizophrenia

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ClinicalTrials.gov Identifier: NCT02108899
Recruitment Status : Recruiting
First Posted : April 9, 2014
Last Update Posted : March 12, 2019
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Brief Summary:

When people are tested on a previously learned material, they will later remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties.

The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia.

If effective, this method could be used in cognitive remediation programs.

Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia.


Condition or disease Intervention/treatment Phase
Schizophrenia Episodic Memory Deficits Behavioral: Retrieval practice effect using descriptive stories and free-call tests without feedback Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 50 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: Retrieval Practice in Patients With Schizophrenia : an Exploratory Study Using Descriptive Stories
Actual Study Start Date : May 2014
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory Schizophrenia

Arm Intervention/treatment
Experimental: Patients with schizophrenia Behavioral: Retrieval practice effect using descriptive stories and free-call tests without feedback

In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

In the second phase (initial test), they recall one text or restudy the other one.

In the third phase (final test) which takes place 2 days later, they recall both texts.


Active Comparator: Healthy subjects Behavioral: Retrieval practice effect using descriptive stories and free-call tests without feedback

In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

In the second phase (initial test), they recall one text or restudy the other one.

In the third phase (final test) which takes place 2 days later, they recall both texts.





Primary Outcome Measures :
  1. Number of items properly recalled [ Time Frame: Final test : 2 days after the first experimental session ]

    - The aim is to investigate the retrieval practice effect using descriptive stories and free-recall tests without feedback in patients with schizophrenia and healthy controls.

    In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

    In the second phase (initial test), they recall one text ("test" condition) or restudy the other one ("re-study" condition).

    In the third phase (final test) which takes place 2 days later, they recall both texts.

    - We will compare in patients with schizophrenia and healthy controls final performance recall (number of items properly recalled) for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).



Secondary Outcome Measures :
  1. Difference between final performance recall and memory span score [ Time Frame: Final test : 2 days after the first experimental session ]

    In each group (patients with schizophrenia and healthy controls) :

    Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.




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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • French is the native language, or acquired before 5 years old
  • People must be able to understand and follow the trial instructions

Specific inclusion criteria (for patients) :

  • Diagnostic of schizophrenia, according to the DSM -5, clinically stable
  • The treatment must remain unchanged during the trial

Exclusion Criteria:

  • Severe or acute cerebral disease
  • Other actual psychiatric disorder
  • Use of drugs with high anticholinergic effect
  • Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
  • Inappropriate use of drugs

Specific exclusion criteria (for healthy subjects) :

- Diagnostic of schizophrenia of a relative up to the third degree


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02108899


Contacts
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Contact: Pierre VIDAILHET, PhD 0388116461 ext +33 pierre.vidailhet@chru-strasbourg.fr

Locations
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France
Service de psychiatrie - Hôpital Civil - CHRU Strasbourg Recruiting
Strasbourg, France, 67091 Cedex
Contact: Pierre VIDAILHET, PhD    0388116461 ext +33    pierre.vidailhet@chru-strasbourg.fr   
Principal Investigator: Pierre VIDAILHET, PhD         
Sub-Investigator: Anne GIERSCH, PhD         
Sub-Investigator: Fabrice BERNA, PhD         
Sponsors and Collaborators
University Hospital, Strasbourg, France

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Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT02108899     History of Changes
Other Study ID Numbers: 5305
First Posted: April 9, 2014    Key Record Dates
Last Update Posted: March 12, 2019
Last Verified: March 2019
Keywords provided by University Hospital, Strasbourg, France:
Schizophrenia
Episodic memory deficits
Additional relevant MeSH terms:
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Memory Disorders
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms