Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting

Personalized Medicine Decision-Making in a Virtual Clinical Setting

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2016 by National Institutes of Health Clinical Center (CC)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ) Identifier:
First received: April 5, 2014
Last updated: August 3, 2016
Last verified: June 2016


How people respond to drugs depends in part on their genes. For some drugs, doctors can use an individuals genetic background to help in dosing the drug. Researchers want to know how doctors incorporate personalized or genomic medicine into clinical practice.


To study how physicians make personalized treatment decisions


Healthy adult primary care physicians who are internal (or family) medicine residents.


Participants will complete a screening form.

Participants will put on a headset, called a head-mounted display, showing a virtual reality environment.

The environment will contain an exam room and the virtual patient.

After interacting with the virtual patient, participants will complete a series of survey measures.

Participation will last for about 60 minutes. The virtual patient interaction and follow-up questions will be audio taped.

Deep Vein Thrombosis
Blood Clots

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Medical Decision-Making in a Virtual Clinical Setting

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Primary Outcome Measures:
  • To examine how physicians make treatment plan decisions for patients with DVT. [ Time Frame: Ongoing ] [ Designated as safety issue: No ]

Estimated Enrollment: 260
Study Start Date: March 2014
Estimated Study Completion Date: July 2018
Estimated Primary Completion Date: July 2017 (Final data collection date for primary outcome measure)
Detailed Description:
This study will examine factors related to primary care physicians clinical decision-making. Using a virtual clinical interaction experiment, we aim to better understand physicians decision-making processes and to explore their communication behaviors toward patients in the clinical encounter. Physician participants will enter a virtual exam room where they will be asked to respond to a virtual patient, acting as her primary care physician, in a follow-up visit after she experienced a deep venous thrombosis (DVT). Various aspects of physician communication in the virtual clinic and self-report measures related to decision-making will be analyzed.

Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
  • All physicians will be healthy adult volunteers who are medical residents in the internal medicine specialty.


  1. persons with seizure or vestibular disorders;
  2. persons who are highly prone to motion sickness;
  3. those without normal or normal to corrected vision or hearing;
  4. all current and past employees and contractors of NHGRI; and
  5. persons who have received information about the study purpose or procedure from a past participant.

NHGRI employees are excluded for this protocol because they are likely to have specialized genomic knowledge and may think differently about genomics in the clinical interaction.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT02108041

Contact: Vence L Bonham, J.D. (301) 594-3973

United States, Maryland
Johns Hopkins School of Medicine Recruiting
Baltimore, Maryland, United States, 21205
United States, Massachusetts
Harvard School of Public Health Recruiting
Boston, Massachusetts, United States, 02115
United States, Michigan
University of Michigan, School of Public Health Recruiting
Ann Arbor, Michigan, United States, 48109-2029
United States, New York
Columbia University Recruiting
New York, New York, United States, 10032-3784
Sponsors and Collaborators
National Human Genome Research Institute (NHGRI)
Principal Investigator: Vence L Bonham, J.D. National Human Genome Research Institute (NHGRI)
  More Information

Responsible Party: National Human Genome Research Institute (NHGRI) Identifier: NCT02108041     History of Changes
Other Study ID Numbers: 999914075  14-HG-N075 
Study First Received: April 5, 2014
Last Updated: August 3, 2016
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Pharmacogenetic Testing
Communicative Behaviors

Additional relevant MeSH terms:
Venous Thrombosis
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases processed this record on October 21, 2016