Working... Menu

Depotentiation in People With Focal Hand Dystonia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02106936
Recruitment Status : Terminated
First Posted : April 8, 2014
Last Update Posted : July 2, 2017
Prachaya Srivanitchapoom, MD
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )

Brief Summary:


- Focal hand dystonia (FHD) causes muscles to contract, leading to abnormal movements or postures. Musicians, writers, and athletes often get it. Researchers want to study how patients with this condition learn, a process of the brain that depends on a property called plasticity.


- To study brain plasticity in people with FHD.


  • Right-handed adults 18 years and older with FHD.
  • Healthy, right-handed adult volunteers.


  • Participants will be screened with medical history, physical exam, pregnancy test, and questionnaire about their right-handedness.
  • Participants will have 2 study visits on 2 different days.
  • Participants will sit in a chair and have up to 30 Transcranial Magnetic Stimulation (TMS) pulses on the left side of the head. A brief electrical current passes through a wire coil on the scalp. They will hear a click and may feel a pulling on the skin or muscle twitches. They may have to keep their eyes open and remain alert, tense certain muscles, or perform simple finger movements.
  • Forty more pulses, with 10 seconds between, will be given on the left side of the head. Some will be small, some big.
  • Researchers will measure muscle response through small electrodes taped to the right hand.
  • A cloth cap will be put on the participant s head. Researchers will write on tape on the cap.
  • Participants will have the r-PAS. An electrical stimulator will be placed on the nerve at the right wrist. Repeated magnetic pulses will be delivered in trains or short bursts together with electrical stimulation of nerve. Participants will receive up to 840 pulses.
  • Participants will be contacted after a few days for a follow-up check.

Condition or disease
Focal Dystonia Healthy Volunteers

Detailed Description:


Primary objectives:

To explore the proper parameters creating a long-term depression (LTD)-like effect and depotentiation (DePo) by using rapid paired associative stimulation (rPAS) in focal hand dystonia (FHD) patients

Sample Size and Population:

We plan to recruit 28 healthy volunteers (HVs) and 28 FHD patients from the Movement Disorders and Botulinum Toxin (BoNT) clinics of HMCS.


Phase 1 deals with HVs while phase 2 deals with FHD patients. We will complete phase 1 before starting phase 2. Each phase is composed of 2 experiments. In phase 1, experiments 1 and 2 will create the LTD-like effect and DePo in HVs and in phase 2, experiments 3 and 4 will elicit the LTD-like effect and DePo in FHD patients. We will use regression analysis to show that the motor evoked potential (MEP) amplitude declines after eliciting the LTD-like effect and DePo.

Outcome measurements:

Primary outcome:

Determining the parameters for creating the LTD-like effect and DePo in HVs and FHD using rPAS

Secondary outcome:

Measuring the percent change of the MEP amplitude after applying the proper stimulus parameters causing an LTD-like effect and DePo in both HVs and FHD.

Layout table for study information
Study Type : Observational
Actual Enrollment : 6 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Depotentiation in Focal Hand Dystonia Patients
Study Start Date : March 5, 2014
Actual Primary Completion Date : June 20, 2017
Actual Study Completion Date : June 20, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dystonia

Primary Outcome Measures :
  1. Motor evoked potential amplitude [ Time Frame: Immediate ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
  • Must be 18 years or older
  • Must be right-handed
  • FHD includes only writer s cramp
  • Must be able to provide consent
  • No open scalp wounds or scalp infections.
  • Agrees to not drink caffeine or alcohol for 48 hours before study session.


  • Has used illegal drugs within the past 6 months based on history. The intent is to exclude those with drug use that may affect study results. Participants who appear to be intoxicated at the time of testing will be rescheduled.
  • Has more than 7 alcoholic drinks a week in the case of a woman and 14 alcoholic drinks a week in the case of a man.
  • Abnormal findings on neurologic exam (other than dystonia in patient group)
  • Has had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures.
  • Has major depression or any major mental disorders (axis I disorders)
  • Has a neurologic disorder other than dystonia
  • Has had a head injury where there was a loss of consciousness for more than a few seconds.
  • Has metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, or metal fragments in the eye,
  • Has known hearing loss.
  • Pregnancy and lactation
  • Taking any medication that acts as a central nervous system stimulant or that is known to lower seizure threshold, including, imipramine, amitriptyline, doxepine, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, cocaine, (MDMA, ecstasy), phencyclidine (PCP, angel s dust), ketamine, gamma-hydroxybutyrate (GHB), alcohol, theophylline, mianserin, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, reboxetine, venlafaxine, duloxetine, bupropion, mirtazapine, fluphenazine, pimozide, haloperidol, olanzapine, quetiapine, aripiprazole, ziprasidone, risperidone, chloroquine, mefloquine, imipenem, penicillin, ampicillin, cephalosporins, metronidazole, isoniazid, levofloxacin, cyclosporin, chlorambucil, vincristine, methotrexate, cytosine arabinoside, BCNU, lithium, anticholinergics, antihistamines, and sympathomimetics.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02106936

Layout table for location information
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Prachaya Srivanitchapoom, MD
Layout table for investigator information
Principal Investigator: Mark Hallett, M.D. National Institute of Neurological Disorders and Stroke (NINDS)

Layout table for additonal information
Responsible Party: National Institute of Neurological Disorders and Stroke (NINDS) Identifier: NCT02106936     History of Changes
Other Study ID Numbers: 140070
First Posted: April 8, 2014    Key Record Dates
Last Update Posted: July 2, 2017
Last Verified: June 20, 2017

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) ):
Focal Hand Dystonia
Transcranial Magnetic Stimulation (TMS)
Rapid Paired Associative Stimulation
Healthy Volunteer

Additional relevant MeSH terms:
Layout table for MeSH terms
Dystonic Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Movement Disorders
Central Nervous System Diseases