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Knee Pain Phenotypes in the Community Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02098070
Recruitment Status : Unknown
Verified August 2017 by University of Nottingham.
Recruitment status was:  Enrolling by invitation
First Posted : March 27, 2014
Last Update Posted : August 24, 2017
Arthritis Research UK
Information provided by (Responsible Party):
University of Nottingham

Brief Summary:
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over. It will also identify characteristics such as structural changes of osteoarthritis of the knee as well as physiological parameters and blood and urine biomarkers.

Condition or disease
Knee Osteoarthritis

Detailed Description:

Number of participants:

Part I: questionnaire to 40,000 people aged 40 years and over (giving an expected 10,000 respondents) Part II: 400 participants.

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Study Type : Observational
Estimated Enrollment : 40000 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Knee Pain and Related Health in the Community Study
Study Start Date : September 2014
Estimated Primary Completion Date : September 2018
Estimated Study Completion Date : September 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Knee Pain Population
Participants who have responded to the questionnaire with self-reported pain.
Non-Knee Pain Population
Participants who have responded to the questionnaire, no self-reported pain.

Primary Outcome Measures :
  1. Knee Pain Phenotypes [ Time Frame: up to 12 months ]
    The prevalence of the different knee pain phenotypes, provided by specific pain questionnaires. This will include the Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP), the Pain Catastrophizing Scale (PCS) and the PainDetect (for neuropathic pain).

Secondary Outcome Measures :
  1. Other Risk Factors [ Time Frame: up to 12 months ]
    The risk factors for each knee pain phenotype, including age, gender, pain elsewhere, the Hospital Anxiety and Depression Scale (HADS), the pain catastrophizing scale and presence of osteoarthritis risk factors (BMI, finger ratio (2D4D), finger nodes, knee alignment) will be determined from the questionnaires.

Biospecimen Retention:   Samples With DNA
Whole Blood Urine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Community-derived sample

Inclusion criteria:

  • Aged 40 years and over

Exclusion criteria:

  • Inability to give informed consent
  • Terminal or mental illness
  • Pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02098070

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United Kingdom
Academic Rheumatology
Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
Sponsors and Collaborators
University of Nottingham
Arthritis Research UK
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Principal Investigator: Michael Doherty, MD University of Nottingham
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: University of Nottingham Identifier: NCT02098070    
Other Study ID Numbers: 14018
First Posted: March 27, 2014    Key Record Dates
Last Update Posted: August 24, 2017
Last Verified: August 2017
Keywords provided by University of Nottingham:
Knee Pain
Community Study
Knee Osteoarthritis
Risk Factors
Additional relevant MeSH terms:
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Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases