Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty
|ClinicalTrials.gov Identifier: NCT02094339|
Recruitment Status : Unknown
Verified March 2015 by bo xu, Guangzhou General Hospital of Guangzhou Military Command.
Recruitment status was: Recruiting
First Posted : March 21, 2014
Last Update Posted : March 12, 2015
|Condition or disease||Intervention/treatment||Phase|
|Pain Complications||Procedure: Local analgesic Procedure: Nerve Block Procedure: Intravenous analgesic Drug: ropivacaine Drug: opioid||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||45 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial|
|Study Start Date :||March 2014|
|Estimated Primary Completion Date :||June 2016|
|Estimated Study Completion Date :||June 2016|
Experimental: Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
Procedure: Local analgesic
Patient will be performed under combined lumbar plexus and sciatic nerve block with 0.33% ropivacaine.At the end of surgery,two catheters are left in the wound.One is intraarticular and the other is on the surface of articular cavity.And then a pump elastomeric infusion pump will be connected with the catheters, which runs 5mL every hours.
Active Comparator: Nerve Block
People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.
Procedure: Nerve Block
Combined lumbar plexus and sciatic nerve block with 0.33% ropivacaine will be performed before the surgery.After the a bolus of 30mL ropivacaine around lumbar plexus,a catheter will be left in Psoas gap with 6cm.A pump elastomeric infusion pump running 5mL every hours will also be connected with the catheters at the end of the operation.
Active Comparator: Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
Procedure: Intravenous analgesic
People in this group will also receive an anesthesia of combined lumbar plexus and sciatic nerve block with 0.33% ropivacaine.An intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg will will provide postoperative pain management.The patients will received a 2 mL/h continuous basal infusion and 1 mL boluses with a lockout time of 30 min after a 5 mL Loading dose at the end of the surgery.
flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg
- pain [ Time Frame: 72 hours postoperation ]Up to 72 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain.
- sedation [ Time Frame: 72 hours postoperation ]At 2, 4, 6, 12, 24, 36, 48,72 hours after operation,sedation OAA/S scores are used to evaluate the level of sedation.
- complication [ Time Frame: 72 hours postoperation ]Investigators document the incidence of nausea,vomiting,headache,urinary retention and et al.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02094339
|Contact: bo xu, associate chief physician||88653387 ext email@example.com|
|Guangzhou Military Region General Hospital, Department of Anesthesiology||Recruiting|
|Guangzhou, Guangdong, China, 510010|
|Contact: Tao Zhi Li 15625052815 ext 86 firstname.lastname@example.org|