Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu
Trial record 29 of 406 for:    PYY

Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02093416
Recruitment Status : Completed
First Posted : March 21, 2014
Last Update Posted : January 15, 2016
Sponsor:
Information provided by (Responsible Party):
University of Pittsburgh

Brief Summary:

Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants.

The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.


Condition or disease
Obesity

Layout table for study information
Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study
Study Start Date : October 2013
Actual Primary Completion Date : July 2014
Actual Study Completion Date : July 2014

Group/Cohort
Group 1: Control Group
BMI <30 There are 20 controls in this group
Group 2
BMI 30-35 There were 12 controls in this class
Group 3
BMI 35-40 There were 9 controls in this clas
Group 4
BMI >40 There were 9 controls in this class



Primary Outcome Measures :
  1. PCR test for Leptin Receptors [ Time Frame: 1 week ]
    Endoscopic biopsies of enterocytes will be measured via PCR


Secondary Outcome Measures :
  1. ELISA test for ghrelin, motilin, leptin and PYY [ Time Frame: 1 week ]
    Blood samples collected to determine hormones via ELISA

  2. IWQOL lite questionnaire [ Time Frame: 1 week ]
    Quality of Life questionnaire on obesity



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Males and Females undergoing endoscopy
Criteria

Inclusion Criteria:

  • Endoscopic Intervention

Exclusion Criteria:

  • 18 years of age or older
  • No acute GI bleeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02093416


Locations
Layout table for location information
United States, Pennsylvania
University of Pittsburgh/UPMC Presby
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
Investigators
Layout table for investigator information
Principal Investigator: Jennifer L Seminerio, MD University of Pittsburgh

Layout table for additonal information
Responsible Party: University of Pittsburgh
ClinicalTrials.gov Identifier: NCT02093416     History of Changes
Other Study ID Numbers: PRO13010529
First Posted: March 21, 2014    Key Record Dates
Last Update Posted: January 15, 2016
Last Verified: January 2016
Keywords provided by University of Pittsburgh:
Obesity
Leptin
Additional relevant MeSH terms:
Layout table for MeSH terms
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms