S. Aureus Colonization in Atopic Dermatitis
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|ClinicalTrials.gov Identifier: NCT02091037|
Recruitment Status : Unknown
Verified January 2017 by Christine Lauren, Columbia University.
Recruitment status was: Active, not recruiting
First Posted : March 19, 2014
Last Update Posted : February 1, 2017
The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis.
The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.
|Condition or disease|
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to evaluate for S. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents.
Our aim is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance. We will analyze routinely-collected skin culture specimens from children with AD seen at our center and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.
|Study Type :||Observational|
|Estimated Enrollment :||114 participants|
|Official Title:||Staphylococcus Aureus Colonization in Atopic Dermatitis|
|Study Start Date :||December 2011|
|Actual Primary Completion Date :||December 2016|
|Estimated Study Completion Date :||December 2017|
- Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis [ Time Frame: Up to 3 years ]
- Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis [ Time Frame: Up to 20 years ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02091037
|United States, New York|
|Columbia University Medical Center / Department of Dermatology|
|New York, New York, United States, 10032|