Effects of Sedentary Behaviour on Metabolic Parameters
The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effects of Sedentary Behaviour on Metabolic Parameters|
- Blood Pressure [ Time Frame: every 60 minutes for 4 hours ] [ Designated as safety issue: No ]
- C Reactive Protein [ Time Frame: every 60 minutes for 4 hours ] [ Designated as safety issue: No ]
- Insulin Levels [ Time Frame: every 60 minutes for 4 hours ] [ Designated as safety issue: No ]
- Blood glucose levels [ Time Frame: every 60 minutes for 4 hours ] [ Designated as safety issue: No ]
|Study Start Date:||January 2015|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||September 2015 (Final data collection date for primary outcome measure)|
During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes
Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.
During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed)
Subjects will remain inactive (lying on a bed) for 4 hours.
There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.
Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.
This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02088827
|Contact: Gale Tedder, RN, BSNemail@example.com|
|Canada, British Columbia|
|Gerontology Research Lab||Recruiting|
|Vancouver, British Columbia, Canada, V5Z 1M9|
|Contact: Gale Tedder, RN, BSN 604-875-5115 firstname.lastname@example.org|
|Principal Investigator: Kenneth M Madden, MSc, MD|
|Sub-Investigator: Marisa Wan, MD|
|Principal Investigator:||Kenneth M Madden, MSc, MD||University of British Columbia|