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Effect of PRP on the Therapy for Hair Growth

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ClinicalTrials.gov Identifier: NCT02087319
Recruitment Status : Completed
First Posted : March 14, 2014
Last Update Posted : March 2, 2016
Sponsor:
Information provided by (Responsible Party):
China Medical University Hospital

Brief Summary:
The purpose of study is to examine the advantage of PRP on hair loss and male pattern baldness. The investigators will inject PRP into the scalp regions where with little or no hair, and evaluate the effect and efficiency of PRP on human hair growth.

Condition or disease Intervention/treatment Phase
Hair Loss/Baldness Other: hair loss, baldness (patient's own platelet-rich plasma) Not Applicable

Detailed Description:

Hair loss is a disorder in which the hair undergoes aberration growth cycles and falls out from scalp. A number of factors like hormones, genetic factors, diet, endocrine abnormalities, systemic illnesses, drug intake, and hair shaft abnormalities may cause hair loss. Androgen alopecia or male pattern baldness is the most common cause of hair loss caused by progressive shortening of the anagen and increased number of hair follicles in telogen, which has a significant influence on psychological distress.

Except medical treatment and baldness surgery, a new interest in treating hair loss and baldness has been stimulated by using platelet plasma growth factors obtained from the patient's own platelet-rich plasma (PRP). PRP is a portion of plasma fraction of autologous blood having a high concentration of thrombocytes, and can be activated by Thrombin to release multiple growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), and transforming growth factor beta (TGF-β). PRP is known for the capacity to stimulate cell proliferation and differentiation. The action of platelet plasma growth factors on the development of hair follicles has already been established. PRP has also been shown to increase the yield of implanted follicular units during male baldness surgery.

Our study will focus on the advantage of PRP for the treatment of hair loss and male pattern baldness. PRP from autologous blood can be mixed with thrombin in appropriate ratio and inject into the regions on scalp which is interested. We will track and evaluate regularly the effect and efficiency of PRP on human hair growth.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Application and Evaluation of PRP on the Therapy for Hair Loss Disorder
Study Start Date : January 2014
Actual Primary Completion Date : June 2015
Actual Study Completion Date : June 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: platelet-rich plasma
hair loss, baldness
Other: hair loss, baldness (patient's own platelet-rich plasma)
hair loss, baldness




Primary Outcome Measures :
  1. examination the effect of PRP on hair loss/baldness [ Time Frame: 1 month ]
    We will track and evaluate regularly the effect and efficiency of PRP on human hair growing density and newly-formed hair length by phtography and measurement.



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patient with hair loss/baldness
  • age of 20-70 years old

Exclusion Criteria:

  • patient with systemic disorder
  • phyco
  • patient with coagulation abnormality
  • patient with inflammation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02087319


Locations
Taiwan
China Medical University Hospital
Taichung, Taiwan
Sponsors and Collaborators
China Medical University Hospital
Investigators
Study Chair: Jeng Long-Bin organ transplantation center

Responsible Party: China Medical University Hospital
ClinicalTrials.gov Identifier: NCT02087319     History of Changes
Other Study ID Numbers: CMUH102-REC1-111
First Posted: March 14, 2014    Key Record Dates
Last Update Posted: March 2, 2016
Last Verified: February 2016

Additional relevant MeSH terms:
Alopecia
Alopecia Areata
Hypotrichosis
Hair Diseases
Skin Diseases
Pathological Conditions, Anatomical