Gene Expression in the Overactive Bladder in Children
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|ClinicalTrials.gov Identifier: NCT02086058|
Recruitment Status : Unknown
Verified December 2015 by University of Aarhus.
Recruitment status was: Recruiting
First Posted : March 13, 2014
Last Update Posted : December 18, 2015
The aim of this study (the hypothesis) is to identify differences in the gene expression profile in the bladder muscle and hereby gain greater knowledge about the muscular mechanisms that cause overactive bladder and daytime urinary incontinence in children older than 5 years. A secondary aim is to examine how this gene expression profile differs from children with a neurogenic overactive bladder and how the gene expression profile changes from childhood till adulthood. Such new knowledge will result in a more precisely targeted and hence effective treatment of overactive bladder.
The results will be obtained by retrieving bladder biopsies from children and adults suffering from an overactive bladder or a neurogenic bladder. These biopsies will undergo molecular analysis and the investigators will compare them with biopises from bladder healthy adults and children.
|Condition or disease|
|Overactive Bladder Children|
|Study Type :||Observational|
|Estimated Enrollment :||46 participants|
|Official Title:||Gene Expression in the Bladder in Children With an Overactive Bladder and Daytime Urinary Incontinence|
|Study Start Date :||November 2013|
|Estimated Primary Completion Date :||September 2016|
|Estimated Study Completion Date :||November 2016|
- Up- and down regulation of genes expressed in the bladder [ Time Frame: collection of bladder material and analysis will take approximately 2 years ]We will evaluate the gene expression (which genes are up- and/or down regulated) in the bladder in healthy children compared to children suffering from an overactive bladder. This gene expression will then be compared to the gene expression in bladder tissue from adults, to evaluate what happens in the bladder from childhood to adulthood.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02086058
|Contact: Luise Borch, M.D||+45 22 92 55 firstname.lastname@example.org|
|Center for child incontinence, Aarhus University hospital||Recruiting|
|Aarhus, Aarhus N, Denmark, 8200|
|Principal Investigator:||Luise Borch, M.D||University of Aarhus|