Effect of Gastric Bypass Surgery on Cognition and Genetics
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|ClinicalTrials.gov Identifier: NCT02085369|
Recruitment Status : Unknown
Verified May 2016 by Uppsala University.
Recruitment status was: Recruiting
First Posted : March 12, 2014
Last Update Posted : May 12, 2016
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Effect of Gastric Bypass Surgery on Cognition and Genetics|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||March 2017|
|Estimated Study Completion Date :||March 2017|
- Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery) [ Time Frame: 1 year ]Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery
- The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention) [ Time Frame: Measures 1 y, 2 y, and 5 y after surgery. ]No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery
Biospecimen Retention: Samples With DNA
A fasted blood sample (50 mL) will be taken before and 2h after a standardized meal.
Through epigenetic study, we will analyze the changes in DNA methylation after surgery in genes related to metabolism (at the Science for Life Laboratory (SciLifeLab) with 450K Human Meth arrays).
In addition, blood samples from these obese patients analyzed (before and after surgery) after ingestion of a predetermined test meal (for example, high protein) to explore changes in metabolites profile. Metabolites in the samples will be quantified by the SciLifeLab.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02085369
|Contact: Magnus Sundbom, MDfirstname.lastname@example.org|
|Contact: Sofia Kanders, MScemail@example.com|
|Uppsala University Hospital||Recruiting|
|Contact: Magnus Sundbom firstname.lastname@example.org|
|Principal Investigator: Magnus Sundbom, PhD|
|Study Director:||Magnus Sundbom, MD||Academic Hospital Uppsala|
|Study Director:||Pleunie Hogenkamp, PhD||Uppsala University|
|Study Director:||Christian Benedict, PhD||Uppsala University|
|Principal Investigator:||Helgi Schiöth, prof||Uppsala University|