Imaging Neuroinflammation in Epilepsy With Ferumoxytol MRI (IRONMAN)
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|ClinicalTrials.gov Identifier: NCT02084303|
Recruitment Status : Completed
First Posted : March 11, 2014
Last Update Posted : March 14, 2018
|Condition or disease||Intervention/treatment||Phase|
|Epilepsy||Other: Ferumoxytol injection after focal epileptic seizure followed by iron-sensitive MRI||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Imaging Neuroinflammation in Epilepsy With Ferumoxytol MRI|
|Study Start Date :||March 2014|
|Actual Primary Completion Date :||March 29, 2015|
|Actual Study Completion Date :||March 2, 2018|
Ferumoxytol injection after focal epileptic seizure followed by iron-sensitive MRI.
Other: Ferumoxytol injection after focal epileptic seizure followed by iron-sensitive MRI
- Overlap of epileptogenic zone with brain regions that take up ferumoxytol [ Time Frame: up to 48 hours after epileptic seizure ]Ferumoxytol will be injected within one hour of epileptic event and iron-sensitive MRI will be conducted within 48 hours.
- Immunohistochemical evidence of neuroinflammation in brain tissue that has taken up ferumoxytol [ Time Frame: Two years ]Brain tissue removed from those patients who undergo curative epilepsy surgery contains the epileptic focus. Histochemical analysis of abnormal areas of this brain tissue will be analyzed for correlation with areas of ferumoxytol uptake.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02084303
|United States, New Hampshire|
|Dartmouth-Hitchcock Medical Center|
|Lebanon, New Hampshire, United States, 03756|
|Principal Investigator:||Barbara C Jobst, MD||Dartmouth-Hitchcock Medical Center|