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Bipolar Research Study Using MR Imaging

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ClinicalTrials.gov Identifier: NCT02083978
Recruitment Status : Completed
First Posted : March 11, 2014
Last Update Posted : June 3, 2015
Sponsor:
Information provided by (Responsible Party):
Washington University Early Recognition Center

Brief Summary:
In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. Thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

Condition or disease Intervention/treatment
Bipolar Affective Disorder Other: MRI scanning

Detailed Description:
There are relatively few studies evaluating brain structure in bipolar disorder (BD), the results of which have been largely inconsistent, both in terms of what abnormalities are present in BD and whether they show any similar abnormalities to those found in schizophrenia. One possibility that might explain the varying degree of reported similarity in structural findings in schizophrenia and BD is that there might be effects of BPD diagnostic subtype associated with brain structure. One viewpoint that contrasts schizophrenia and BD considers psychotic (PBD) to differ from non-psychotic (NPBD) subtypes in terms of shared pathophysiology with schizophrenia. PBD has been reported as being of special interest, as it shares symptomatic overlap with schizophrenia, "runs in families", shares a chromosomal linkage to the 13q13-32 and 22q12 with schizophrenia, shows similar increases in dopamine receptor Bmax induced by [c-11] N-methylspiperone positron emission tomography and similar working memory impairments as in schizophrenia. If PBP and NPBP are associated with different forms of brain pathology, then merging the two entities into a single "bipolar group" might obscure relevant anatomic differences if these occur primarily in only one group. In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. Thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

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Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Neuromorphometry of Psychosis in Bipolar Disorder
Study Start Date : January 2010
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bipolar Disorder

Group/Cohort Intervention/treatment
Bipolar Diagnosis
Individuals identified as having a Bipolar Diagnosis with a manic episode
Other: MRI scanning
Control
Individuals identified as not having a major psychiatric diagnosis
Other: MRI scanning



Primary Outcome Measures :
  1. subcortical grey and white matter structures [ Time Frame: within one month of study enrollment ]
    Evaluation of the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community Sample
Criteria

Inclusion Criteria:

  • between the ages of 18-30
  • diagnosed with Bipolar Disorder

Exclusion Criteria:

  • history of head injury
  • unstable medical condition

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083978


Locations
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United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University Early Recognition Center
Investigators
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Principal Investigator: Daniel Mamah, M.D, MPE Washington University School of Medicine

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Responsible Party: Washington University Early Recognition Center
ClinicalTrials.gov Identifier: NCT02083978     History of Changes
Other Study ID Numbers: 201105453
First Posted: March 11, 2014    Key Record Dates
Last Update Posted: June 3, 2015
Last Verified: June 2015
Keywords provided by Washington University Early Recognition Center:
Bipolar Disorder
Magnetic Resonance Imaging (MRI) scanning
Additional relevant MeSH terms:
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Bipolar Disorder
Mood Disorders
Bipolar and Related Disorders
Mental Disorders