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Effects of Marihuana Use on Optic Nerve Parameters and Ocular Blood Flow

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ClinicalTrials.gov Identifier: NCT02080676
Recruitment Status : Unknown
Verified October 2015 by Orna Geyer, Carmel Medical Center.
Recruitment status was:  Recruiting
First Posted : March 6, 2014
Last Update Posted : October 14, 2015
Sponsor:
Information provided by (Responsible Party):
Orna Geyer, Carmel Medical Center

Brief Summary:
Purpose of study: to check the effect of medical cannabis given for approved medical indications on ocular parameters including intra ocular pressure, optic nerve fibers thickness and choroidal thickness.

Condition or disease
Intra Ocular Pressure

Detailed Description:

Purpose of study: to check the effect of medical cannabis given for approved medical indications on ocular parameters including intra ocular pressure, Retinal Nerve Fiber Layer (RNFL) thickness, optic nerve fibers thickness and choroidal thickness.

Adult patients with no ocular pathology that are being treated in the neurology or pain clinics with medical cannabis for different indications, were examined in the eye clinic.

First examination took place after the patient was not smoking for 5 hours. Three more examinations took place 1 hour 3 hours and 5 hours after smoking cannabis.

The following parameters were checked: blood pressure, pulse, visual acuity, intra ocular pressure, corneal thickness, axial length, slit lamp examination of anterior segment, fundoscopy and Optical Coherence Tomography (OCT) of the retina, and optic nerve.


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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effects of Marihuana Use on Optic Nerve Parameters and Ocular Blood Flow
Study Start Date : March 2014
Estimated Primary Completion Date : March 2016
Estimated Study Completion Date : May 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana




Primary Outcome Measures :
  1. Intra ocular pressure [ Time Frame: 5 hours ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adult patients over the age of 18, with no ocular pathology that are being treated in the neurology or pain clinics with medical cannabis for different indications.
Criteria

Inclusion Criteria:

  • Age over 18
  • Treated with medical cannabis for approved medical indications

Exclusion Criteria:

  • Known ocular pathology
  • Topical or systemic treatment for intra ocular pressure
  • Previous topical, intra ocular or systemic steroid treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02080676


Contacts
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Contact: Orna Geyer, MD 97248250926 orna_geyer@clalit.org.il

Locations
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Israel
Carmel Medical Center Recruiting
Haifa, Israel
Contact: Nurit Mathalone, MD    97248250477    Nurit.Mathalone@clalit.org.il   
Principal Investigator: Orna Geyer, MD         
Sponsors and Collaborators
Carmel Medical Center
Investigators
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Principal Investigator: Orna Geyer, MD Carmel Medical Center

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Responsible Party: Orna Geyer, Professor, Carmel Medical Center
ClinicalTrials.gov Identifier: NCT02080676     History of Changes
Other Study ID Numbers: CMC-14-0001-CTIL
First Posted: March 6, 2014    Key Record Dates
Last Update Posted: October 14, 2015
Last Verified: October 2015

Keywords provided by Orna Geyer, Carmel Medical Center:
Cannabis
Intra ocular pressure
Ocular perfusion
Blood pressure

Additional relevant MeSH terms:
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Marijuana Use
Substance-Related Disorders
Mental Disorders