The Role of Ninjurin-1 During Systemic Inflammation (Ninj1)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02079597|
Recruitment Status : Completed
First Posted : March 6, 2014
Last Update Posted : September 3, 2014
- With the underlying study the investigators address the question if Ninjurin-1 (Ninj1) expression is altered in patients with systemic inflammatory response syndrome (SIRS) in comparison to healthy volunteers.
- The adhesion molecule Ninj1 is induced following nerve injury where it contributes to nerve generation. Besides it is described to facilitate leukocyte migration especially in the nervous system.
- The investigators hypothesize that Ninj1 expression is increased in SIRS patients, which will fortify its impact during inflammation and the transferability from bench to bedside.
|Condition or disease|
|Ninj1 Expression SIRS|
|Study Type :||Observational|
|Actual Enrollment :||30 participants|
|Observational Model:||Case Control|
|Official Title:||Prospective Study to Analyze Ninjurin-1 and Its Soluble Part During Systemic Inflammation|
|Study Start Date :||February 2014|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||September 2014|
Healthy individuals no infection
SIRS patients no included in an interventional study no peroperative infection
- Ninj1 expression on blood leukocytes [ Time Frame: one day post surgery ]
- grade of systemic inflammation [ Time Frame: one day post surgery ]routine inflammatory markers will be used to evaluate the grade of inflammation e.g. procalcitonin (PCT) Interleukin 6, lipopolysaccharide (LPS) binding protein (LBP). Retrospective evaluation for sepsis (bacterial infection)
- Soluble Ninj1 concentration/expression rates [ Time Frame: one day post surgery ]Concentration will be measured in plasma samples as well as from whole blood culture incubated with 100 ng/ml lipopolysaccharide for 6, 16 and 24 h.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02079597
|Department of Anesthesiology, University Hospital Frankfurt|
|Frankfurt, Hessen, Germany, 60596|
|Principal Investigator:||Patrick Meybohm, MD||Department of Anesthesiology, University Hospital Frankfurt|