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Attention Bias Modification Treatment for Major Depression Disorder in Adolescents

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ClinicalTrials.gov Identifier: NCT02078258
Recruitment Status : Unknown
Verified August 2014 by Wenhui Yang, Hunan Normal University.
Recruitment status was:  Enrolling by invitation
First Posted : March 5, 2014
Last Update Posted : August 21, 2014
Sponsor:
Information provided by (Responsible Party):
Wenhui Yang, Hunan Normal University

Brief Summary:
In this study, we test whether a two-week 8-session attention bias modification (ABM) training could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups.

Condition or disease Intervention/treatment Phase
Major Depressive Disorder, Single Episode, Unspecified Behavioral: dot-probe task Not Applicable

Detailed Description:
Depression is a common health problem in adolescents. Attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in adolescents, we designed a randomized, double-blind, placebo controlled trial in depressed adolescents.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 45 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Attention Bias Modification Treatment for Major Depression Disorder in Adolescents: A Randomized Controlled Trial
Study Start Date : September 2012
Estimated Primary Completion Date : September 2014
Estimated Study Completion Date : September 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Attentional bias modification training
Participants complete 8 sessions of dot-probe task attention bias modification training (ABMT) during a two-week period. ABMT is a modified dot probe task, in which a probe always appears in the location of neutral stimulus after the two stimuli (i.e. one is the depressive cue and the other is neutral) were simultaneously presented. In the ABMT,the probability that a probe appears in the location of neutral is 90%, and correspondingly,in the location of depressive stimuli is 10%. Each session consists of 320 trials, and the time to complete a training session is approximately 20 minutes.
Behavioral: dot-probe task
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.

Placebo Comparator: Placebo control
Participants complete 8 sessions of placebo training(PT) during a two-week period. Placebo training is a classic dot-probe task, in which a probe appears after either of the locations that the two stimuli (i.e. one is the depressive cue and the other is neutral) were presented, with the same frequencies. In the PT condition, each session also consists of 320 trials, and the time to complete a PT session is approximately 20 minutes as well.
Behavioral: dot-probe task
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.




Primary Outcome Measures :
  1. Changes in depressive symptom number measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS) [ Time Frame: baseline, 7-week, 6-month follow-up ]
  2. Changes in depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS) [ Time Frame: baseline, 7-week, 6-month follow-up ]

Secondary Outcome Measures :
  1. Self-report symptoms measured by the Center for Epidemiologic Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T),Rumination Response Style(RRS),Suicidal Ideation Questionnaire(SIQ) [ Time Frame: baseline, 7-week, 6-, 12-month follow-up ]
  2. Diagnostic status of major depressive disorder assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children [ Time Frame: baseline, 7-week, 6-month follow-up ]


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Ages Eligible for Study:   11 Years to 19 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Meet the major depression disorder's criteria

Exclusion Criteria:

  • bipolar disorder, schizophrenia or organic mental disorder;
  • any concurrent psychotherapy;
  • any concurrent psychotropic medication.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02078258


Locations
China, Hunan
Department of Psychology, Hunan Normal University
Changsha, Hunan, China, 400081
Sponsors and Collaborators
Hunan Normal University
Investigators
Study Director: Wenhui Yang, Ph.D, MD. Hunan Normal University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Wenhui Yang, Department of Psychology, Hunan Normal University
ClinicalTrials.gov Identifier: NCT02078258     History of Changes
Other Study ID Numbers: 1
First Posted: March 5, 2014    Key Record Dates
Last Update Posted: August 21, 2014
Last Verified: August 2014

Keywords provided by Wenhui Yang, Hunan Normal University:
depression,adolescent,attention bias,modification

Additional relevant MeSH terms:
Disease
Depression
Depressive Disorder
Depressive Disorder, Major
Pathologic Processes
Behavioral Symptoms
Mood Disorders
Mental Disorders