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Dyslipidemia-related Risk Factors in Dialysis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02072837
Recruitment Status : Completed
First Posted : February 27, 2014
Last Update Posted : February 28, 2014
Information provided by (Responsible Party):
Vaia D.Raikou, National and Kapodistrian University of Athens

Brief Summary:
In this study, we studied lipoprotein abnormalities-related variables as risk factors for the development of cardiovascular disease in patients on renal replacement therapies.We studied 96 dialyzed patients, 62 males and 34 females, on mean age 62.1 years old and 24 healthy controls.We concluded that metabolic acidosis activating the inflammation and lipoprotein oxidation influences the dyslipidemia and cardiovascular morbidity of patients on renal replacement therapies.Dialysis adequacy was positively associated to cardioprotective HDL.Peritoneal dialysis holds a better acidosis level and lower oxidized lipids than hemodialysis modalities.

Condition or disease
Chronic Renal Disease Cardiovascular Disease Dyslipidemia

Detailed Description:

Blood samples were obtained by venipuncture in the peritoneal dialyzed patients and control group in a twelve hours fasting state.In hemodialyzed patients blood was drawn just before the start of the mean weekly dialysis session also in a twelve hours fasting state from the vascular access.

All samples were received once at baseline time ( in the start of the study ). Peripheral systolic and diastolic blood pressures were calculated as an average of 10 measurements during a renal replacement treatment month in the starting time of the study.

Also, electrocardiographic examination, echocardiography and the calculation of ankle-brachial blood pressure index became once in the start of the study.

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Study Type : Observational
Actual Enrollment : 96 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Dyslipidemia-related Variables as Risk Factor for Cardiovascular Disease in Patients on the End-stage of Renal Disease
Study Start Date : January 2012
Actual Primary Completion Date : January 2014
Actual Study Completion Date : January 2014

Primary Outcome Measures :
  1. Associations between dyslipidemia with cardiovascular disease on patients on renal replacement therapy [ Time Frame: February 2014 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   24 Years to 87 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We studied 96 dialyzed patients at Nephrology Department of "Laiko, University General Hospital of Athens" and Renal Unit of "Diagnostic and Therapeutic Center of Athens Hygeia SA". 62 males and 34 females participated in this study.The treatment modalities which were applied were : regular haemodialysis (HD, n=34), predilution haemodiafiltration (HDF, n=42) and peritoneal dialysis (PD, n=20).

Inclusion Criteria:

  • permanent renal replacement therapy more than 6 months and
  • accurate dry body weight

Exclusion Criteria:

  • acute illness,
  • significant infection,
  • malignancy,
  • Kt/V for urea <1.2.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02072837

Sponsors and Collaborators
National and Kapodistrian University of Athens
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Principal Investigator: Vaia D. Raikou, Ph.D National & Kapodistrian University of Athens, School of Medicine
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Responsible Party: Vaia D.Raikou, Ph.D Nephrologist; Researcher, National and Kapodistrian University of Athens Identifier: NCT02072837    
Other Study ID Numbers: E.S.931/5-12-2006
First Posted: February 27, 2014    Key Record Dates
Last Update Posted: February 28, 2014
Last Verified: February 2014
Keywords provided by Vaia D.Raikou, National and Kapodistrian University of Athens:
hemodialysis, dyslipidemia, cardiovascular disease
Additional relevant MeSH terms:
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Kidney Diseases
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Cardiovascular Diseases
Urologic Diseases
Lipid Metabolism Disorders
Metabolic Diseases
Renal Insufficiency