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Future of Beta Cells in Adults With Genetic Abnormality Behind Neonatal Diabetes (GLUCONEO)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Assistance Publique - Hôpitaux de Paris Identifier:
First received: November 4, 2013
Last updated: April 15, 2016
Last verified: April 2016
The main objective of this study is to evaluate Beta cells in patients with a neonotal diabetes linked to a genetic abnormality Metabolic caracteristics will described using a transversal cohort study.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Devenir au Long Cours de la Cellule bêta Chez Les Adultes Porteurs d'Anomalies génétiques à l'Origine du Diabète Néonatal

Resource links provided by NLM:

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Primary Outcome Measures:
  • Mean insulin secretion output [ Time Frame: Week after inclusion ]

Secondary Outcome Measures:
  • insulin secretion outout after arginine perfusion [ Time Frame: during hospitalisation (3 days) ]
  • sensitivity to insulin [ Time Frame: during hospitalisation (3 days) ]
  • glucago secretion output [ Time Frame: during hospitalisation (3 days) ]

Enrollment: 17
Study Start Date: December 2012
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Adult with neonatal diabetes
Adult with neonatal diabetes (before 1 year ) and need for insulin
non diabetic adults with a relative with neonatal diabetes


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
diabetic people

Inclusion Criteria:

  • Age : 18 à 65 year
  • diabetic patient with a neonatal diabetis (before 1 year old) and need for insuline or patient with a relative having neonatal diabetis

Exclusion Criteria:

Diabète induit (médicaments - ex corticoïdes) ou syndromique

  • infection
  • cancer
  • pegnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT02072551

Hopital Siant-louis
Paris, France, 75010
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
  More Information

Responsible Party: Assistance Publique - Hôpitaux de Paris Identifier: NCT02072551     History of Changes
Other Study ID Numbers: GLUCONEO
Study First Received: November 4, 2013
Last Updated: April 15, 2016 processed this record on September 25, 2017