Vestibular and Multisensory Influence on Bodily and Spatial Representations
|ClinicalTrials.gov Identifier: NCT02072460|
Recruitment Status : Unknown
Verified February 2014 by Assistance Publique Hopitaux De Marseille.
Recruitment status was: Active, not recruiting
First Posted : February 26, 2014
Last Update Posted : February 26, 2014
The present project aims at describing how vestibular signals contribute to the multisensory mechanisms of bodily self-consciousness.
There is a large body of data regarding the sensory and neural mechanisms of self-consciousness, but most studies have so far demonstrated the contribution of visual, tactile and proprioceptive signals to bodily self-consciousness. Thus, most studies have neglected the contribution of the vestibular system, a major sensory system for spatial and bodily representations. The vestibular system is sensitive to head motions in space and head inclinations with respect to gravity and it should therefore contribute significantly to several bodily experiences. This contribution should be put under neuroscientific scrutiny. We believe that the current neuroscientific models of bodily self-consciousness will be incomplete until they incorporate the contribution of vestibular signals.
The present project specifically aims at testing the hypothesis according to which vestibular signals significantly influence bodily self-consciousness, in particular first-person and third-person perspective taking and the internal body models (i.e. the body schema and body image). The present project also aims at describing how cortical vestibular processing is modified during experimental changes of perspective taking and viewpoint. In addition, the present project will describe whether vestibular disorders change performances in third-person perspective taking tasks and modify internal body models. This should help understanding bodily symptoms in vestibular-defective patients. To this end, we will combine approaches from psychophysics and electrophysiology (electromyography, electroencephalography) in healthy volunteers and behavioral approached in patients with vestibular disorders.
These studies should further the understanding of how the brain processes vestibular signals, which is to date poorly understood. In addition, the outcome of the present project should help understanding the multiple and complex symptoms reported by patients with vestibular diseases, and should therefore improve their treatment.
|Condition or disease||Intervention/treatment||Phase|
|Vestibular Disorders||Other: electromyography Other: electroencephalography Other: approaches from psychophysics||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||80 participants|
|Intervention Model:||Factorial Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Supportive Care|
|Official Title:||Vestibular and Multisensory Influence on Bodily and Spatial Representations. Behavioral and Electrophysiological Investigations in Vestibular-defective Patients and Healthy Volunteers|
|Study Start Date :||February 2014|
|Estimated Primary Completion Date :||July 2017|
Experimental: vestibular signals determination
vestibular signals determination by electromyography and electroencephalography associated to approaches from psychophysics
|Other: electromyography Other: electroencephalography Other: approaches from psychophysics|
- vestibular signals [ Time Frame: 48 months ]testing the hypothesis according to which vestibular signals significantly influence bodily self-consciousness, in particular first-person and third-person perspective taking and the internal body models (i.e. the body schema and body image).
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02072460
|Assistance Publique Hopitaux de Marseille|
|Marseille, France, 13354|
|Study Director:||Loïc MONDOLONI||Assistance Publique Hopitaux De Marseille|