Mixed Tree Nut Food Challenges
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|ClinicalTrials.gov Identifier: NCT02070263|
Recruitment Status : Enrolling by invitation
First Posted : February 25, 2014
Last Update Posted : January 10, 2019
|Condition or disease|
To evaluate the absence of tree nuts (TN) allergy, referred patients from one of the Arkansas Children's Hospital (ACH) Allergy Clinic physicians with current serum immunoglobulin E (IgE) to TNs that meet eligibility criteria will be invited to undergo a series of open mixed TN food challenges.
A questionnaire pertaining to their TN allergy will be administered
A brief physical exam will be performed.
Skin prick tests using selected nut allergen extracts along with a positive (histamine) and a negative (salt-water) control will be performed at the first oral food challenge visit.
Each food challenges will be performed to 1 to 3 TNs.
Two telephone follow-up phone calls will evaluate inclusion/exclusion of tree nuts in the diet post food challenge.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Mixed Tree Nut Food Challenges|
|Study Start Date :||April 2009|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||December 2020|
- Oral tolerance to selected tree nuts (TN) to determine potential predictors of oral tolerance. [ Time Frame: total -20 years ]This prospective, observational study uses serum IgE to specific TN, skin prick test to TN, and TN oral food challenges to establish oral tolerance.
- Use of tree nut (TN) IgE testing to assess the risk of positive food challenges based on grouped mixed TN food challenges [ Time Frame: total - 20 years ]We postulate that by grouping TN that are mixed into one food challenge based on the individual's TN serum IgE will be more efficient in defining TN allergy and tolerance. One to three TNs will be in one food challenge based on TN IgE testing.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02070263
|United States, Arkansas|
|Arkansas Children's Hospital|
|Little Rock, Arkansas, United States, 72202|
|Principal Investigator:||Stacie M Jones, MD||University of Arkansas for Medical Sciences / Arkansas Children's Hospital|