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Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

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ClinicalTrials.gov Identifier: NCT02068261
Recruitment Status : Unknown
Verified October 2015 by Rickard Ahlberg, Örebro Läns Landsting.
Recruitment status was:  Recruiting
First Posted : February 21, 2014
Last Update Posted : October 23, 2015
Sponsor:
Information provided by (Responsible Party):
Rickard Ahlberg, Örebro Läns Landsting

Brief Summary:
The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Condition or disease Intervention/treatment Phase
Substance Abuse Executive Dysfunction Anxiety Depression Antisocial Personality Reading Disabilities Behavioral: Computerized Cogmed working memory training Behavioral: Treatment as usual Phase 2

Detailed Description:
The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial.
Study Start Date : January 2014
Estimated Primary Completion Date : December 2016
Estimated Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Arm Intervention/treatment
Experimental: Cogmed working memory training
30-40 minutes of Cogmed computerized working memory training 3-5 days a week for 5-8 weeks. Every training session consists of a set of visual- and verbal working memory tasks that are trained on during the session.
Behavioral: Computerized Cogmed working memory training
Computerized working memory training with Cogmed QM software. The QM software consists of a set of verbal and visual working memory tasks which is trained for 25-40 minutes each session.

Active Comparator: Treatment as usual
Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment. After a 8 week period participants in this arm well be offered Cogmed working memory training.
Behavioral: Treatment as usual
Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment.




Primary Outcome Measures :
  1. Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA). [ Time Frame: Baseline and at 25 weeks ]

Secondary Outcome Measures :
  1. Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale. [ Time Frame: Baseline and at 25 weeks ]
  2. Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index. [ Time Frame: Baseline and at 25 weeks ]
  3. Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index. [ Time Frame: Baseline and at 25 weeks ]
  4. Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales. [ Time Frame: Baseline and at 25 weeks ]
  5. Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A). [ Time Frame: Baseline and at 25 weeks ]
  6. Change from baseline in verbal working memory measured with performance on Digit span. [ Time Frame: Baseline and at 25 weeks ]
  7. Change from baseline in visual working memory measured with performance on Span board. [ Time Frame: Baseline and at 25 weeks ]
  8. Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II). [ Time Frame: Baseline and at 25 weeks ]
  9. Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II). [ Time Frame: Baseline and at 25 weeks ]
  10. Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version). [ Time Frame: Baseline and at 25 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Treatment seeking adults with substance abuse and executive function deficits.

Exclusion Criteria:

  • Acute intoxication or abstinence symptoms of any substance.
  • Psychosis.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02068261


Contacts
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Contact: Rickard Ahlberg, doctoral student rickard.ahlberg@orebroll.se
Contact: Kurt Skårberg, MD kurt.skarberg@orebroll.se

Locations
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Sweden
Psychiatric Research Centre Recruiting
Örebro, Sweden, 701 16
Contact: Rickard Ahlberg, doctoral student       rickard.ahlberg@orebroll.se   
Principal Investigator: Lars Kjellin, docent         
Sponsors and Collaborators
Örebro Läns Landsting
Investigators
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Study Director: Lars Kjellin, Docent Örebro Läns Landsting

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Responsible Party: Rickard Ahlberg, Clinical psychologist, doctoral student., Örebro Läns Landsting
ClinicalTrials.gov Identifier: NCT02068261     History of Changes
Other Study ID Numbers: RA02
First Posted: February 21, 2014    Key Record Dates
Last Update Posted: October 23, 2015
Last Verified: October 2015

Additional relevant MeSH terms:
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Dyslexia
Substance-Related Disorders
Antisocial Personality Disorder
Chemically-Induced Disorders
Mental Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Neurodevelopmental Disorders
Personality Disorders