Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
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|ClinicalTrials.gov Identifier: NCT02066558|
Recruitment Status : Completed
First Posted : February 19, 2014
Last Update Posted : February 12, 2015
|Condition or disease||Intervention/treatment||Phase|
|Headache Migraine||Other: Carbon monoxide Other: Placebo||Not Applicable|
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Basic Research on Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model|
|Study Start Date :||February 2014|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
Active Comparator: carbon monoxide
Inhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.
Other: Carbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass.
Placebo Comparator: placebo
- Headache scores [ Time Frame: 12 h ]Comparison between carbon monoxide and placebo (atmospheric air)
- Blood flow velocity [ Time Frame: 0-180 min after inhalation ]Carbon monoxide induced changes in blood flow velocity in the middle cerebral artery before and after inhalation.
- Artery circumference [ Time Frame: 0-180 min ]Carbon monoxide induced changes in the superficial temporal artery and the radial artery before and after inhalation.
- Facial blood flow [ Time Frame: 0-180 min ]Carbon monoxide induced changes in facial blood flow before and after inhalation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02066558
|Danish Headache Center|
|Glostrup, Denmark, 2600|
|Principal Investigator:||Nanna Arngrim, MD||Danish Headache Center, Glostrup Hospital|