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Effects of Cocoa Flavanol on Skin Aging

This study has been completed.
Information provided by (Responsible Party):
Jin Ho Chung, Seoul National University Hospital Identifier:
First received: February 9, 2014
Last updated: June 11, 2016
Last verified: June 2016

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.

Condition Intervention
Dietary Supplement: Cocoa flavanol beverage
Dietary Supplement: Placebo beverage

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of 24-week Cocoa Flavanol Supplementation on Photo-aged Facial Skin

Further study details as provided by Jin Ho Chung, Seoul National University Hospital:

Primary Outcome Measures:
  • Change from baseline in skin wrinkles at week 24 [ Time Frame: baseline, week 24 ]
    Facial wrinkles in the crow's feet area measured as R1-3

Secondary Outcome Measures:
  • Change from baseline in skin elasticity at week 24 [ Time Frame: baseline, week 24 ]
    Facial elasticity measured as R2, R5, R7

  • Change from baseline in minimal erythema dose at week 24 [ Time Frame: baseline, week 24 ]
  • Change from baseline in skin hydration at week 12 [ Time Frame: baseline, week 12 ]
    Skin hydration measured by Corneometer

  • Change from baseline in skin color at week 12 [ Time Frame: baseline, week 12 ]
    Skin color measured as erythema index and melanin index

Enrollment: 64
Study Start Date: February 2014
Study Completion Date: March 2015
Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Cocoa flavanol beverage
flavanol 320mg/day
Dietary Supplement: Cocoa flavanol beverage
Other Name: High-flavanol cocoa
Placebo Comparator: Placebo beverage
no flavanol
Dietary Supplement: Placebo beverage


Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy females aged ≥ 40 years
  • Facial wrinkle grade ≥ 2

Exclusion Criteria:

  • received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
  • reported taking functional foods 1 month before the study
  • history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes
  • history of allergies against any component of trial foods
  • any visible skin disease that might be confused with a skin reaction to the test procedure
  Contacts and Locations
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Please refer to this study by its identifier: NCT02060097

Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110744
Sponsors and Collaborators
Seoul National University Hospital
Principal Investigator: Jin Ho Chung, MD, PhD Seoul National University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Jin Ho Chung, Professor, Seoul National University Hospital Identifier: NCT02060097     History of Changes
Other Study ID Numbers: N0000697
Study First Received: February 9, 2014
Last Updated: June 11, 2016

Keywords provided by Jin Ho Chung, Seoul National University Hospital:
High-flavanol cocoa processed this record on May 25, 2017