Discovering the Antecedents of Rheumatoid Arthritis Flare
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Longitudinal study of patients with rheumatoid arthritis comparing measures of disease activity with blood samples.
Condition or disease
80% of patients living with rheumatoid arthritis can expect fluctuations in their symptoms over time. Dramatic increases in disease activity are considered flare. This study will follow patients with increased risk for flare prospectively for one year. Serial questionnaires and disease activity scores will be compared to blood samples to better understand the molecular phenotype of rheumatoid arthritis flares.
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Layout table for eligibility information
Ages Eligible for Study:
40 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
2010 criteria for Rheumatoid Arthritis
Swelling of at least one joint and or elevated acute phase reactants
Greater than or equal to 40 years old or less than or equal to 65 year old female sex
cyclic citrullinated peptide antibody + in the past 12 months
hemoglobin < 9
white blood cell count < 3.5
Diagnosis of any active malignancy within the last 3 years besides non-melanomatous skin cancer
Diagnosis of diabetes and requires insulin
HIV+, Hep B S Ag+, Hep C polymerase chain reaction +
Untreated latent tuberculosis
Diagnosis of any additional systemic autoimmune connective tissue disease
Inability to reliably complete study requirements
History, physical, social or laboratory findings suggestive of any other medical or psychological condition that would, in the opinion of the principal investigator, make the candidate ineligible for the study