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Trial record 5 of 32 for:    Stain | "Parkes Weber syndrome" OR "Vascular Malformations"

Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples

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ClinicalTrials.gov Identifier: NCT02051101
Recruitment Status : Active, not recruiting
First Posted : January 31, 2014
Last Update Posted : February 14, 2018
Sponsor:
Collaborator:
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine

Brief Summary:
The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.

Condition or disease Intervention/treatment Phase
Port-Wine Stain Other: Biopsy sample from Port Wine Stain Birthmark Not Applicable

Detailed Description:
The researcher can detect the defects in nervous system innervation to cutaneous blood vessels contribute to the pathogenesis of Port Wine Stain . Unveiling the pathogenic mechanisms of PWS is crucial to the design of new therapeutic strategies and can use the results to improve current PWS therapeutic outcomes.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples
Study Start Date : May 2013
Estimated Primary Completion Date : November 2018
Estimated Study Completion Date : November 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Biopsy

Arm Intervention/treatment
Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark
Other: Biopsy sample from Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark




Primary Outcome Measures :
  1. Characterization of Port Wine Stain Birthmark tissue sample [ Time Frame: up to 4 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male or female of all ages.
  • Not pregnant.
  • Has diagnosis of port wine stain on the arms, legs, chest, bac.
  • Ability to understand and carry out subject instructions.
  • Subject willing to have skin biopsies on port wine stain and normal skin areas.

Exclusion Criteria:

  • Pregnant women.
  • Port Wine Stain on the face.
  • History of skin cancer.
  • Current participation in an investigational drug evaluation
  • Concurrent use of known photosensitizing drugs.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02051101


Locations
United States, California
Beckman Laser Institute
Irvine, California, United States, 92612
Sponsors and Collaborators
University of California, Irvine
Beckman Laser Institute University of California Irvine
Investigators
Study Director: John s Nelson, MD Beckman Laser Institute, UCI
Principal Investigator: Winbin Tan, PhD Beckman Laser Institute

Responsible Party: Beckman Laser Institute and Medical Center, Wenbin Tan, Ph.D. Project Scientist, University of California, Irvine
ClinicalTrials.gov Identifier: NCT02051101     History of Changes
Other Study ID Numbers: NIH/LAMMP-2013-9396
First Posted: January 31, 2014    Key Record Dates
Last Update Posted: February 14, 2018
Last Verified: February 2018

Additional relevant MeSH terms:
Port-Wine Stain
Vascular Malformations
Hemangioma, Capillary
Skin Abnormalities
Congenital Abnormalities
Skin Diseases
Hemangioma
Neoplasms, Vascular Tissue
Neoplasms by Histologic Type
Neoplasms
Cardiovascular Abnormalities
Cardiovascular Diseases