Computational Tools for Early Diagnosis of Memory Disorders (ProsKuopio)
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|ClinicalTrials.gov Identifier: NCT02050464|
Recruitment Status : Completed
First Posted : January 30, 2014
Last Update Posted : May 4, 2017
|Condition or disease|
|Alzheimer Disease Frontotemporal Dementia Dementia, Vascular Mild Cognitive Impairment|
The Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) is a four-year IT-project funded through the European Union (EU). The project will develop multiscale models of the ageing brain in order to account simultaneously for the patient-specific biochemical, metabolic and biomechanical brain substrate, as well as for genetic, clinical, demographic and lifestyle determinants. An integrated clinical decision support platform will be validated and tested by access to a dozen databases of international cross-sectional and longitudinal studies.
Modeling approaches developed by using the retrospective databases will be tested using a new prospective cohort that will be collected in Kuopio as a part of the VPH-DARE@IT project. The study population at university of Eastern Finland (UEF) will be a total of 120 subjects: 20 healthy controls (HC), 20 mild to moderate Alzheimer's disease (AD) patients, 20 vascular dementia (VAD) patients, 20 fronto-temporal dementia (FTD) patients and 40 subjects with mild cognitive impairment (MCI). This study is referred as VPH-DARE@IT Prospective study in Kuopio or "ProsKuopio".
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||126 participants|
|Target Follow-Up Duration:||18 Months|
|Official Title:||Virtual Physiological Human (VPH) Dementia Research Enabled by IT - Prospective Cohort Kuopio|
|Study Start Date :||December 2013|
|Actual Primary Completion Date :||April 2017|
|Actual Study Completion Date :||April 2017|
Patients with mild Alzheimer's disease
Patients with vascular dementia
Patients with fronto-temporal dementia
Mild cognitive impairment
Patients with mild cognitive impairment
- Sensitivity, specificity and accuracy of models for diagnosis of memory disorders [ Time Frame: during a single visit, i.e., day 1 and for one study group (MCI) after 18 month follow-up ]The models developed the VPH-DARE project will be tested in this prospective cohort. Sensitivity, specificity and accuracy of the model will be tested in differential diagnosis between the study groups as well as the accuracy of prediction cognitive decline as measured by neuropsychological test battery in the MCI group.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02050464
|Department of Neurology and Brain Research Unit, Institute of Clinical Medicine, University of Eastern Finland|
|Kuopio, Finland, FI-70211|
|Kuopio University Hospital|
|Kuopio, Finland, FI-70211|
|VTT Technical Research Centre of Finland|
|Principal Investigator:||Hilkka Soininen, Professor||University of Eastern Finland|