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Trial record 60 of 75 for:    "Collagen Disease" | "Triamcinolone"

Daily Activity After Corticosteroids Injection Among Knee Osteoarthritis Patients

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ClinicalTrials.gov Identifier: NCT02049879
Recruitment Status : Completed
First Posted : January 30, 2014
Last Update Posted : March 3, 2014
Sponsor:
Information provided by (Responsible Party):
Philippe Corbeil, Laval University

Brief Summary:
The objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. Fourteen patients with unilateral knee osteoarthritis were recruited. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Medical Outcome Study Short Form-36 (MOS-SF36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.

Condition or disease Intervention/treatment Phase
Knee Osteoarthritis Drug: Corticosteroids injection Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Quantification of Daily Physical Activity After an Intra-articular Corticosteroid Injection in Patients With Knee Osteoarthritis
Study Start Date : November 2008
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Injection
Corticosteroids injection
Drug: Corticosteroids injection
A solution of triamcinolone 40 mg (Kenalog) mixed with 3 cc of 2% xylocaine without epinephrine.




Primary Outcome Measures :
  1. Change in Knee pain [ Time Frame: Change from Baseline at 2, 4 and 6 weeks ]
  2. Change in physical activity [ Time Frame: Change from baseline at 2, 4 and 6 weeks ]

Secondary Outcome Measures :
  1. Change in function and quality of life [ Time Frame: Change from baseline at 2, 4 and 6 weeks ]
    Assessment with WOMAC and MOS-SF36 questionnaires

  2. Change in Spatiotemporal gait parameters [ Time Frame: Change from Baseline at 2, 4 and 6 weeks ]
    Gait symmetry was verified with regards to the swing and stance phase durations and step length



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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 50 years old or more
  • Medial knee osteoarthritis (Kellgren & Lawrence Grade I to III)

Exclusion Criteria:

  • Intra-articular injection during the last six months
  • Isolated femoro-patellar arthritis
  • Rheumatoid arthritis
  • Knee instability
  • Spinal stenosis
  • Lower limb fracture over the last year
  • Lower limb surgery in the last three months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02049879


Locations
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Canada
Pavillon de l'Éducation Physique et des Sports - Université Laval
Quebec, Canada, G1V 0A6
Sponsors and Collaborators
Laval University
Investigators
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Study Director: Philippe Corbeil, PhD Laval University
Principal Investigator: Yoann Dessery, MSc Laval University
Study Director: Étienne Belzile, MD Laval University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Philippe Corbeil, Professor, Laval University
ClinicalTrials.gov Identifier: NCT02049879     History of Changes
Other Study ID Numbers: INF-2010
First Posted: January 30, 2014    Key Record Dates
Last Update Posted: March 3, 2014
Last Verified: February 2014

Additional relevant MeSH terms:
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Osteoarthritis
Osteoarthritis, Knee
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases