The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the high risk population or suspected patients. Trained dogs will sniff serum from participants who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed by pathological examination.The results will be compared with the outcome of the pathological examination.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients|
- sensitivity and specificity of the sniff dogs as a tool in diagnosing tumors [ Time Frame: 12 months ] [ Designated as safety issue: No ]The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination as non-cancer subjects.
- behavior patterns of the sniff dogs to different diseases [ Time Frame: 12 months ] [ Designated as safety issue: No ]The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination.
- the substances used for identifying tumors by the sniff dogs [ Time Frame: 12 months ] [ Designated as safety issue: No ]GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from non-cancer subjects, the suspected VOCs will be tested by the dog for conformation.
Biospecimen Retention: Samples Without DNA
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||August 2014|
|Estimated Primary Completion Date:||August 2014 (Final data collection date for primary outcome measure)|
Healthy volunteers measured by currently used healthy screening procedures
Suspected breast cancer subjects
Suspected breast cancer subjects without pathological examination yet but will have it soon
Suspected lung cancer subjects
Suspected lung cancer subjects without pathological examination yet but will have it soon
Suspected neurological tumor subjects
Suspected neurological tumor subjects without pathological examination yet but will have it soon
Suspected patients with gynecological tumor
Suspected subjects with gynecological tumors without pathological examination yet but will have it soon
Please refer to this study by its ClinicalTrials.gov identifier: NCT02049658
|Contact: Chang-Qing Gao, MD PhD||86 188 7486 firstname.lastname@example.org|
|Contact: Ya-Qin Wang, MD PhD||86 email@example.com|
|Center for Scientific Research with Animal Models, CSU||Recruiting|
|Changsha, Hunan, China, 410008|
|Contact: Chang-Qing Gao, MD PhD 86 188 7486 9488 firstname.lastname@example.org|
|Contact: Ya-Qin Wang, MD PhD 152 7481 0930 email@example.com|
|Principal Investigator: Chang-Qing Gao, MD PhD|
|Principal Investigator:||Chang-Qing Gao, MD PhD||Central South University|