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Trial record 17 of 126 for:    "Viral Infectious Disease" | "Ethanol"

Investigation of the Role of Human Papilloma Virus (HPV) in the Prognosis of Head and Neck Cancer (ARCAGE-NWE)

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ClinicalTrials.gov Identifier: NCT02049177
Recruitment Status : Completed
First Posted : January 30, 2014
Last Update Posted : September 8, 2016
Sponsor:
Collaborator:
International Agency for Research on Cancer
Information provided by (Responsible Party):
University of Aberdeen

Brief Summary:

Human papilloma virus (HPV) is a recognised cause of some head and neck cancers. Important questions remain however, regarding the role of specific types of HPV, their effect on prognosis and different subtypes of oral, pharyngeal and laryngeal cancer, interaction with other risk factors (such as smoking and alcohol), and potential geographical differences in the effect of HPV.

Via the Alcohol-Related Cancers and Genetic Susceptibility in Europe (ARCAGE) study, which is an international collaboartive case-control study conducted in 15 centres in 11 European countries, and pooling our results with the HPV-AHEAD consortium, we will conduct a systematic analysis of HPV subtypes known or suspected to be involved in head and neck cancer. This will involve investigation of HPV risk by tumour site (oral, oropharynx, hypopharynx, larynx), tumour stage, country, sex and age, and whether risk is modified by exposure to other known or suspected carcinogens including tobacco, alcohol and medical history.

It is intended that this work will contribute to the development of evidence that may feed into treatment protocols for these cancers as well as evaluations of the feasibility for extending HPV vaccine programs.


Condition or disease
Head and Neck Cancer

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Study Type : Observational
Actual Enrollment : 141 participants
Observational Model: Case-Only
Official Title: Alcohol Related Cancers and Genetic Susceptibility in Europe Follow-up - North-West England
Study Start Date : November 2013
Actual Primary Completion Date : April 2014
Actual Study Completion Date : April 2014

Resource links provided by the National Library of Medicine


Group/Cohort
Head and Neck Cancer Cases
Cases of Head and Neck Cancer identified in North West England in 2002/2003. Observational study - no intervention other than usual care.



Primary Outcome Measures :
  1. HPV type [ Time Frame: From surgical/biopsy samples taken in 2002/2003, to be typed in 2014 ]

Secondary Outcome Measures :
  1. Vital status [ Time Frame: 2014 ]
  2. Cancer Reccurrence [ Time Frame: 2002-2014 ]
  3. Secondary cancers [ Time Frame: 2002-2014 ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cases that were previously identified for the HPV-AHEAD case-control study.
Criteria

Inclusion Criteria:

  • Consent to follow-up and use of tissue samples

Exclusion Criteria:

  • No existing consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02049177


Locations
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United Kingdom
Royal Blackburn Hospital
Blackburn, United Kingdom
Blackpool Victoria Infirmary
Blackpool, United Kingdom
Manchester Royal Infirmary
Manchester, United Kingdom
North Manchester General Hospital
Manchester, United Kingdom
The Christie Hospital
Manchester, United Kingdom
Royal Preston Hospital
Preston, United Kingdom
Sponsors and Collaborators
University of Aberdeen
International Agency for Research on Cancer

Additional Information:
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Responsible Party: University of Aberdeen
ClinicalTrials.gov Identifier: NCT02049177     History of Changes
Other Study ID Numbers: 2/084/13
First Posted: January 30, 2014    Key Record Dates
Last Update Posted: September 8, 2016
Last Verified: September 2016
Keywords provided by University of Aberdeen:
Cancer
Epidemiology
Head and Neck
HPV
Additional relevant MeSH terms:
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Head and Neck Neoplasms
Neoplasms by Site
Neoplasms