Brain Biomarkers of Response to Treatment for Apraxia of Speech (SPT)
The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Brain Biomarkers of Response to Treatment for Apraxia of Speech|
- Percent change in naming score for trained and untrained items [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]For each participant, three target sounds will be chosen, and these may be single consonants, vowels, or clusters at the word level. Twenty items for each speech sound will be developed: 10 which will serve as Trained items and 10 which will serve as untrained items. The trained and untrained items will be balanced according to syllabic structure, word frequency, grammatical form class, and stress pattern. The trained items will allow us to measure acquisition effects, and the untrained items will allow us to measure generalization effects of SPT.
- Change in fractional anisotropy [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]To measure neuroplasticity associated with the speech treatment protocol, we will calculate the difference in fractional anisotropy values from pre- to post-treatment for each of the eight fiber tracts in the left hemisphere.
|Study Start Date:||March 2014|
|Estimated Study Completion Date:||March 2018|
|Estimated Primary Completion Date:||January 2017 (Final data collection date for primary outcome measure)|
Experimental: Speech Production Treatment
This treatment employs a response-contingent hierarchy made up of verbal modeling/repetition, graphic cueing, integral stimulation, and articulatory placement instruction. We chose this treatment for the following reasons: 1) rigor of development demonstrated across multiple studies, 2) large and predictable effects with published, quantified effect sizes, 3) a demonstrated pattern of generalization to untrained items, illustrating experimental control, 4) an established multi-modal stimulation protocol, and 5) use of repeated practice, which is associated with neural plasticity.
Behavioral: Speech Production Treatment
This treatment employs a response-contingent hierarchy made up of verbal modeling/repetition, graphic cueing, integral stimulation, and articulatory placement instruction.
The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, we will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02046941
|Contact: Stephanie Brown||(916) 843-9340||Stephanie.Brown01@va.gov|
|Contact: Jary Larsen||(916) 366-5333|
|United States, California|
|VA Northern California Health Care System, Mather, CA||Recruiting|
|Sacramento, California, United States, 95655|
|Contact: Stephanie Brown 916-843-9340 Stephanie.Brown01@va.gov|
|Principal Investigator: Juliana V. Baldo, PhD|
|Principal Investigator:||Juliana V. Baldo, PhD||VA Northern California Health Care System, Mather, CA|