Calcium Ionophore Solution Can Increase Fertilization Rate in Patients During Intracytoplasmic Sperm Injection(ICSI) Who Have Poor Ovarian Reserve?
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02045914|
Recruitment Status : Unknown
Verified January 2014 by Pinar Caglar Aytac, Baskent University.
Recruitment status was: Recruiting
First Posted : January 27, 2014
Last Update Posted : January 27, 2014
|Condition or disease||Intervention/treatment||Phase|
|Fertilization Failure||Other: calcium ionophore solution||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||162 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Calcium Ionophore Solution on Fertilization Rate During ICSI Cycles of Poor Ovarian Reserve Patients|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||April 2014|
|Estimated Study Completion Date :||August 2014|
No Intervention: control group
the patients who have no intervention with calcium ionophore during ICSI cycle
Experimental: calcium ionophore
the patients whose oocytes are incubated with calcium ionophore solution during ICSI cycle
Other: calcium ionophore solution
After microinjection of sperm into the oocyte, oocytes are incubated for 15 minutes in a 30 microlitre droplet of calcium ionomycin solution
- calcium ionophore solution effect on fertilization rate [ Time Frame: 18 hours ]Before Intracytoplasmic sperm injection adding calcium ionophore solution to the medium can increase fertilization rate of oocytes or not?
- Calcium ionophore solution increase on going pregnancy rate [ Time Frame: up to 21 weeks ]İf the calcium ionophore can increase fertilization rate , pregnancy rate up to 20 weeks, can increase or not?
- calcium ionophore can decrease fertilization rate [ Time Frame: 18 hours ]To detect if calcium ionophore can affect fertilization rate in a reverse manner than expected
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02045914
|Contact: Pinar Caglar Aytac, MDfirstname.lastname@example.org|
|baskent university obstetric and gynecology, reproductive endocrinology and IVF unit||Recruiting|
|Adana, Kisla, Turkey, 01230|
|Principal Investigator: pinar caglar aytac|
|Study Director:||esra bulgan kilicdag, prof md||Baskent University|
|Study Chair:||Huriye Ayse Parlakgumus, md||Baskent University|
|Principal Investigator:||Pinar Caglar Aytac, md||Baskent University|
|Study Chair:||Cok Tayfun, md||Baskent University|
|Study Chair:||Bulent Haydardedeoglu, assoc Prof||Baskent University|
|Study Chair:||Erhan Simsek, md||Baskent University|