Computed Tomography Angiography to Brain Death Assessment
The purpose of this study is to assess the reliability of computed tomography angiography (CTA) to diagnose brain death, face of several conditions that make impossible to define such diagnosis using clinical criteria exclusively.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Computed Tomography Angiography to Brain Death Assessment|
- Assess the presence or absence of contrast medium filling of the intracranial vessels in comatose patients. [ Time Frame: 1 year ] [ Designated as safety issue: No ]After excluding confounding factors, we will submit comatose patients to CTA. Immediately after the exam, we will perform clinical evaluation for brain death and calculate CTA sensibility and specificity for this diagnosis. Time between these two interventions will be measured.
|Study Start Date:||November 2013|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||July 2015 (Final data collection date for primary outcome measure)|
Critically ill patients, presenting Glasgow Coma Score 5 or lower, will be submitted to the Computed Tomography Angiography (CTA) of the skull assessment, and follow a clinical evaluation for brain death, additionally, transcranial Doppler would be applied as the gold standard for brain death.
We will exclude patients whose do not can be submitted to contrast injection, or if a brain death clinical evaluation has been performed prior the CTA.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02045407
|Contact: Sergio Brasil, MDfirstname.lastname@example.org|
|Hospital das Clínicas da Faculdade de Medicina da USP.||Recruiting|
|São Paulo, Brazil, 05403000|
|Contact: Sergio Brasil, MD 5511981210990 email@example.com|
|Principal Investigator:||Sergio Brasil, MD||University of São Paulo, School of Medicine.|