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Nutritional Metabolomics: the Search for Dietary Exposure Variables 2

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ClinicalTrials.gov Identifier: NCT02039609
Recruitment Status : Completed
First Posted : January 17, 2014
Last Update Posted : August 15, 2018
Sponsor:
Information provided by (Responsible Party):
Göteborg University

Brief Summary:
In the post-genomic era, a major challenge for health research is to understand the complex interactions among genetic, environmental and lifestyle factors including dietary intake. Unfortunately, such initiatives are hampered by the lack of accurate dietary intake assessment methods for large studies. The newly emerging field of metabolomics offers unique possibilities to characterize individual food intake, dietary patterns and effects of dietary intervention in large studies. The investigators propose to develop a platform to detect broad metabolomic responses to food intake in controlled trials as well as to use targeted metabolomics approaches to characterize dietary intake in longitudinal studies. Our laboratory has a long history of developing methodology for assessing nutritional status and effects of diet on metabolism. Here, the investigators team up with the Sahlgrenska Academy Core Facility and the Swedish NMR Centre at the University of Gothenburg, that offer modern metabolomics equipment and competence in bioinformatics, and use this in the context of nutrition research. To their knowledge, the investigators are among the first groups in the country to develop skills in metabolomics to assess dietary intake and effects of nutrition on metabolism, and probably the first to use two complementary platforms with both mass-spectrometry and nuclear magnetic spectroscopy. Hence, our methodological results should be useful to nutritional scientists nationally as well as internationally.

Condition or disease
Healthy

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Study Type : Observational
Actual Enrollment : 120 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Nutritional Metabolomics: the Search for Dietary Exposure Variables 2
Actual Study Start Date : February 2013
Actual Primary Completion Date : December 2015
Actual Study Completion Date : January 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vegetarian Diet

Group/Cohort
Omnivores
No intervention, habitual diet
Vegetarians
No intervention, habitual diet
Vegans
No intervention, habitual diet
Vegetarians consuming fish
No intervention, habitual diet



Primary Outcome Measures :
  1. Metabolomic patterns that reflect habitual diet [ Time Frame: Fasting blood sample in the morning at one occasion ]
    Long-time vegans, vegetarians and omnivores will be asked to donate a fasting blood sample at one occasion, in the early morning. This blood sample will be analyzed, using nuclear magnetic resonance (NMR) and mass spectrometry (MS) techniques to reveal all metabolites. Patterns among these metabolites will be distinguished using the statistical techniques principal component analysis and discriminant analysis.


Secondary Outcome Measures :
  1. Discriminating vegan-, vegetarian- and omnivorous diets by hair isotopic analysis [ Time Frame: Hair samples in the morning at one occasion ]
    The same study group also was asked to donate 5-10 hairs of 2 cm closest to the scalp. These were analyzed using isotope ratios of 15N and 13C by IRMS, to see if also this method could discriminate between the groups


Biospecimen Retention:   Samples With DNA
Whole blood


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy subjects Adults
Criteria

Inclusion Criteria:

Healthy Body mass index 18.0-30.0, age 18-65 yrs

Exclusion Criteria:

Regular Medication or tobacco use Pregnancy or lactating


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02039609


Locations
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Sweden
Dept Internal Medicine and Clinical Nutrition, Univ of Gothenburg
Göteborg, Sweden, S-40530
Sponsors and Collaborators
Göteborg University
Investigators
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Principal Investigator: Anna K Winkvist, PhD Univ of Gothenburg, Sweden
Study Chair: Lars H Ellegard, PhD, MD Univ of Gothenburg, Sweden
Study Director: Helen M Lindqvist Univ of Gothenburg, Sweden
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Göteborg University
ClinicalTrials.gov Identifier: NCT02039609    
Other Study ID Numbers: Nutritional Metabolomics AIKN2
First Posted: January 17, 2014    Key Record Dates
Last Update Posted: August 15, 2018
Last Verified: August 2018
Keywords provided by Göteborg University:
vegetarian
vegan
omnivore
Habitual diet