Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Protein and Recovery From Exercise-induced Muscle Damage

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02034721
Recruitment Status : Completed
First Posted : January 13, 2014
Last Update Posted : December 13, 2016
Sponsor:
Collaborator:
Herbalife International of America, Inc.
Information provided by (Responsible Party):
Appalachian State University

Brief Summary:
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle damage and accelerate recovery. This study will determine if supplementation with Herbalife 24 Rebuild Strength (compared to placebo) before, during, and after a 90-minute bout of eccentric exercise attenuates exercise-induced muscle damage, inflammation, and delayed onset of muscle soreness (DOMS), speeds recovery of muscle function, and maintains immune function in NASCAR pit crew athletes (Hendrick Motor Sports).

Condition or disease Intervention/treatment Phase
Muscle Damage Inflammation Dietary Supplement: Protein supplement Dietary Supplement: Placebo Not Applicable

Show Show detailed description

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Influence of Protein-amino Acid Supplementation on Recovery From Exercise-induced Muscle Damage in NASCAR Pit Crew Athletes
Study Start Date : December 2013
Actual Primary Completion Date : February 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Protein supplementation
60 grams protein before, during, after eccentric exercise
Dietary Supplement: Protein supplement
24 g protein before, 12 g during, and 24 g after eccentric exercise
Other Name: Herbalife Rebuild Strength

Placebo Comparator: Placebo
60 grams placebo before, during, after eccentric exercise
Dietary Supplement: Placebo
Placebo




Primary Outcome Measures :
  1. Muscle damage [ Time Frame: 4 days ]
    Serum myoglobin and creatine kinase will be measured pre- and post-eccentric exercise, and each morning during three days recovery.


Secondary Outcome Measures :
  1. Muscle function [ Time Frame: 4 days ]

    Measured pre- and post-eccentric exercise, and each morning during 3 days of recovery.

    1. Kneeling medicine ball toss.
    2. Vertical jump.
    3. Wingate anaerobic power cycling test.

  2. Muscle soreness [ Time Frame: 4 days ]

    Measured pre- and post-eccentric exercise, and during each morning during 3 days recovery.

    DOMS will be self-reported by the subjects using a 10-point Likert-scale questionnaire (Res Quart Exerc Sport 1993;64:103-107).


  3. Inflammation [ Time Frame: 4 days ]

    Measured from blood samples taken pre- and post-eccentric exercise, and each morning during 3 days recovery.

    Serum C-reactive protein (CRP) will be analyzed by the clinical hematology laboratory at the Carolina Medical Center (Charlotte, NC). CRP will be measured using an LX-20 clinical analyzer (Beckman Coulter Electronics, Brea, CA). Total plasma concentrations of interleukin-6 will be determined using an electrochemiluminescence based solid-phase sandwich immunoassay (Meso Scale Discovery, Gaithersburg, MD).


  4. Innate immune function [ Time Frame: 4 days ]

    Will be measured from blood samples taken pre- and post-eccentric exercise, and each morning during 3 days of recovery.

    Granulocyte and monocyte phagocytosis (G-PHAG, M-PHAG), and oxidative burst activity (G-OBA, M-OBA) will be assayed at the immunology laboratory at UNC-Charlotte (Dr. Didier Dreau).




Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • NASCAR pit crew members/recruits from Hendrick Motorsports
  • Agree to avoid use of other protein supplements during the 4-day study

Exclusion Criteria:

  • Heart problem or told by an MD not to engage in vigorous exercise
  • History of allergies to milk or soy products

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02034721


Locations
Layout table for location information
United States, North Carolina
ASU-NCRC Human Performance Lab
Kannapolis, North Carolina, United States, 28081
Sponsors and Collaborators
Appalachian State University
Herbalife International of America, Inc.
Investigators
Layout table for investigator information
Principal Investigator: David C. Nieman, DrPH Appalachian State University
Additional Information:
Layout table for additonal information
Responsible Party: Appalachian State University
ClinicalTrials.gov Identifier: NCT02034721    
Other Study ID Numbers: 14-0098
First Posted: January 13, 2014    Key Record Dates
Last Update Posted: December 13, 2016
Last Verified: January 2015
Keywords provided by Appalachian State University:
Muscle damage
Muscle soreness
Muscle function
Innate immune function
Inflammation
Additional relevant MeSH terms:
Layout table for MeSH terms
Inflammation
Pathologic Processes