Human Breastmilk in Children Receiving a Bone Marrow Transplant (MILK)
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The investigators hypothesize that children receiving human milk will maintain a greater diversity of helpful bacteria in their gut and have lower levels of inflammatory proteins in the blood compared with children not receiving human milk.
Condition or disease
Bone Marrow Transplant- Autologous or Allogeneic
Phase 1Phase 2
The investigators hypothesize that the gut microbiota during bone marrow transplant could be influenced by administration of enteral donor breast milk. This study will attempt to address this hypothesis, by feeding donor breast milk to young children undergoing transplant, and serially comparing the gut micobiota in children receiving human milk, with those receiving conventional feeding.
Donor breast milk will be pasteurized prior to use.
Given orally or by nasogastric (NG) or nasojejunal (NJ) tube.
Feeding will be supervised and will be advanced as quickly as tolerated with a goal of providing 40-50% of nutritional needs from the donor milk.
It is recognized that the volume of enteral feeds will need to be adjusted per patient tolerance.
A registered dietician will supervise milk provision, and additional calories will be provided by addition of the supplement Prolacta. To make 28 kcal/oz milk, 40 ml of Prolacta will be mixed with 60 ml human milk to make a total volume of 100 ml.
If a nursing mother enrolls on the study, maternal and not donor milk will be given in the maximum volume possible, with Prolacta supplementation if clinically indicated and recommended by the registered dietician.
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Layout table for eligibility information
Ages Eligible for Study:
up to 5 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Children less than 5 years old receiving transplant (autologous or allogeneic)