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Study of Magnetic Brain Stimulation in Treatment of Obsessive Compulsive Disorder (rTMS)

This study is currently recruiting participants.
See Contacts and Locations
Verified May 2016 by University of Manitoba
Manitoba Medical Service Foundation
Information provided by (Responsible Party):
University of Manitoba Identifier:
First received: December 10, 2013
Last updated: May 19, 2017
Last verified: May 2016

In a preliminary pilot study, the investigators tested the efficacy of rTMS over the medial prefrontal cortex in symptom profiles of obsessive compulsive disorder (OCD) patients. This study revealed considerable benefit in using rTMS for the treatment of OCD.

In the current proposal, in a randomized clinical trial, the investigators aim to further evaluate the efficacy of rTMS in OCD in a larger sample size and for a longer period. Studies into the efficacy of rTMS in other psychiatric disorders such as depression have consistently shown that extension of the treatment to four weeks significantly increased the effect size. In the pilot study, the investigators applied rTMS for only two weeks. Although all patients consistently showed improvement in their symptoms, none of them showed complete remission of their OCD. Here, the investigators hypothesize that longer duration of rTMS treatment will have greater benefit in OCD symptom reduction.

Condition Intervention
Obsessive Compulsive Disorder Device: Transcranial Magnetic Stimulation Device: Sham Transcranial Magnetic Stimulation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Efficacy of Deep Repetitive Transcranial Magnetic Stimulation in Treatment of Obsessive Compulsive Disorder, a Double Blind Randomized Clinical Trial

Resource links provided by NLM:

Further study details as provided by University of Manitoba:

Primary Outcome Measures:
  • Change in obsessive and compulsive symptom severity (Yale-Brown Obsessive Compulsive Scale) [ Time Frame: Recordings: baseline; after two weeks of rTMS; after four weeks of rTMS; monthly for three months following the last session of rTMS ]

Estimated Enrollment: 30
Study Start Date: January 2014
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: September 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation
Device: Transcranial Magnetic Stimulation
A non-invasive method for brain stimulation
Sham Comparator: Sham rTMS
Sham Transcranial Magnetic Stimulation
Device: Sham Transcranial Magnetic Stimulation
Sham stimulation of the brain.

Detailed Description:

The purpose of study is to examine the efficacy of rTMS over the medial prefrontal cortex in the treatment of OCD.

rTMS will be provided to OCD patients in a randomized double blind controlled setting, and the investigators hypothesize that in this setting the treatment group would still show significant improvement in OCD symptoms as compared to the sham group.

rTMS will be applied for four weeks on OCD patients and the investigators will assess improvement after four weeks of rTMS. The investigators hypothesize that patients will show significantly greater improvement after four weeks of rTMS vs. two weeks of rTMS.


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosed obsessive compulsive disorder
  • Not currently receiving cognitive behavioural therapy
  • Not currently on any medication or only taking one selective serotonin reuptake inhibitor (SSRI)

Exclusion Criteria:

  • History of psychotic episodes
  • History of neurological illness
  • Previous head injury
  • Active alcohol or substance abuse
  • History of seizure disorders
  • Currently pregnant
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT02018185

Canada, Manitoba
St. Boniface Hospital Recruiting
Winnipeg, Manitoba, Canada, R3P2B4
Contact: Benjamin Meek, BSc MA    2042372975   
Principal Investigator: Mandana Modirrousta, MD PhD FRCPC         
Sponsors and Collaborators
University of Manitoba
Manitoba Medical Service Foundation
  More Information

Responsible Party: University of Manitoba Identifier: NCT02018185     History of Changes
Other Study ID Numbers: B2013:144
Study First Received: December 10, 2013
Last Updated: May 19, 2017

Additional relevant MeSH terms:
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Pathologic Processes
Personality Disorders
Mental Disorders
Anxiety Disorders processed this record on August 23, 2017