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Study of Magnetic Brain Stimulation in Treatment of Obsessive Compulsive Disorder (rTMS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02018185
Recruitment Status : Suspended (Recruitment has been suspended in order to perform interim data analysis.)
First Posted : December 23, 2013
Last Update Posted : September 20, 2019
Manitoba Medical Service Foundation
Information provided by (Responsible Party):
University of Manitoba

Brief Summary:

In a preliminary pilot study, the investigators tested the efficacy of rTMS over the medial prefrontal cortex in symptom profiles of obsessive compulsive disorder (OCD) patients. This study revealed considerable benefit in using rTMS for the treatment of OCD.

In the current proposal, in a randomized clinical trial, the investigators aim to further evaluate the efficacy of rTMS in OCD in a larger sample size and for a longer period. Studies into the efficacy of rTMS in other psychiatric disorders such as depression have consistently shown that extension of the treatment to four weeks significantly increased the effect size. In the pilot study, the investigators applied rTMS for only two weeks. Although all patients consistently showed improvement in their symptoms, none of them showed complete remission of their OCD. Here, the investigators hypothesize that longer duration of rTMS treatment will have greater benefit in OCD symptom reduction.

Condition or disease Intervention/treatment Phase
Obsessive Compulsive Disorder Device: Transcranial Magnetic Stimulation Device: Sham Transcranial Magnetic Stimulation Not Applicable

Detailed Description:

The purpose of study is to examine the efficacy of rTMS over the medial prefrontal cortex in the treatment of OCD.

rTMS will be provided to OCD patients in a randomized double blind controlled setting, and the investigators hypothesize that in this setting the treatment group would still show significant improvement in OCD symptoms as compared to the sham group.

rTMS will be applied for four weeks on OCD patients and the investigators will assess improvement after four weeks of rTMS. The investigators hypothesize that patients will show significantly greater improvement after four weeks of rTMS vs. two weeks of rTMS.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Efficacy of Deep Repetitive Transcranial Magnetic Stimulation in Treatment of Obsessive Compulsive Disorder, a Double Blind Randomized Clinical Trial
Actual Study Start Date : January 2014
Actual Primary Completion Date : December 2018
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation
Device: Transcranial Magnetic Stimulation
A non-invasive method for brain stimulation

Sham Comparator: Sham rTMS
Sham Transcranial Magnetic Stimulation
Device: Sham Transcranial Magnetic Stimulation
Sham stimulation of the brain.

Primary Outcome Measures :
  1. Change in obsessive and compulsive symptom severity (Yale-Brown Obsessive Compulsive Scale) [ Time Frame: Recordings: baseline; after two weeks of rTMS; after four weeks of rTMS; monthly for three months following the last session of rTMS ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosed obsessive compulsive disorder
  • Not currently receiving cognitive behavioural therapy
  • Not currently on any medication or only taking one selective serotonin reuptake inhibitor (SSRI)

Exclusion Criteria:

  • History of psychotic episodes
  • History of neurological illness
  • Previous head injury
  • Active alcohol or substance abuse
  • History of seizure disorders
  • Currently pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02018185

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Canada, Manitoba
St. Boniface Hospital
Winnipeg, Manitoba, Canada, R3P2B4
Sponsors and Collaborators
University of Manitoba
Manitoba Medical Service Foundation

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Responsible Party: University of Manitoba Identifier: NCT02018185     History of Changes
Other Study ID Numbers: B2013:144
First Posted: December 23, 2013    Key Record Dates
Last Update Posted: September 20, 2019
Last Verified: November 2018
Additional relevant MeSH terms:
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Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Pathologic Processes
Personality Disorders
Mental Disorders
Anxiety Disorders