MRI in Diagnosing and Monitoring CIDP
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Magnetic Resonance Imaging and Ultrasound Imaging of Peripheral Nerves in Patients Treated With Immunoglobulin in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.|
- DTI changes in nerves and muscles [ Time Frame: At enrolment ] [ Designated as safety issue: No ]Diffusion Tension Imaging (DTI) in peripheral nerves and muscles in the lower extremities in CIDP patients treated with SCIG will be compared to healthy controls
- Changes in MRI findings between treated and untreated CIDP patients [ Time Frame: All patients are examined at enrolment. Untreated patients are re-examined after 4 months of treatment ] [ Designated as safety issue: No ]
Comparing changes in MTR and DTI between CIDP patients treated with subcutaneous immunoglobulin to those untreated.
The untreated patients will be examined again after 4 months of treatment with immunoglobulin
- Comparing clinical findings to MRI [ Time Frame: At enrolment ] [ Designated as safety issue: No ]
Clinical evaluation by:
Isokinetic dynamometry Clinical MRC score
These findings wil be compared to findings on MRI to assess an eventual correlation
|Study Start Date:||May 2014|
|Estimated Study Completion Date:||October 2015|
|Estimated Primary Completion Date:||September 2015 (Final data collection date for primary outcome measure)|
CIDP - treated
Patients diagnosed with CIDP and fulfilling the criteria by EFNS and PNS and in maintenance treatment with subcutaneous immunoglobulin
Healthy, gender and age matched controls
CIDP - untreated
Patients newly diagnosed with CIDP and untreated are treated with immunoglobulin and re-examined after 4 months of treatment
Chronic inflammatory neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG).
CIDP is diagnosed by electrophysiology which is time-consuming and unpleasant for the patient.
New techniques suggest that Magnetic Resonance Imaging (MRI) and ultrasound imaging can be used to detect injuries in the peripheral nerves
We want to study if MRI and ultrasound is able to detect damages in peripheral nerves, nerve roots and plexus in patients with CIDP.
Moreover, we want to compare these findings to healthy matched controls and to see if treatment with immunoglobulin changes findings in MRI
Please refer to this study by its ClinicalTrials.gov identifier: NCT02017769
|Department of Neurology, Aarhus University Hospital|
|Aarhus, Denmark, 8000|
|Principal Investigator:||Henning Andersen, Prof, DMSc|