Motor Learning in Stroke

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Department of Veterans Affairs Identifier:
First received: December 16, 2013
Last updated: May 6, 2015
Last verified: May 2015

Stroke is one of the leading causes of chronic disability in veterans. Stroke is associated with significant loss of mobility, increased risk of falling, cardiovascular disease, depression and neuro-cognitive impairment. These deficits negatively impact the independent completion of the Activities of Daily Living (ADLs). Task-oriented training has emerged as the dominant therapeutic intervention in the rehabilitation of chronic stroke victims. The effectiveness of these interventions may be enhanced through facilitation of implicit knowledge rather than explicit knowledge. Specifically, implicit learning increases retention and improves transfer of the improved motor function outside of the lab environment. Moreover, implicit motor control reduces the burden imposed on cognitive resources as the skill is performed automatically (i.e. do not have to 'think' about it). The amount and type of feedback individuals receive while learning a new task (or relearning in the case of rehabilitation) has been shown to influence the type of learning (i.e. implicit or explicit). Thus the purpose of the current study is to determine the effect of different types of feedback during motor learning on the learning type and the resultant impact on functional outcomes (i.e. motor performance, retention, and cognitive workload) in chronic stroke patients.

Condition Intervention Phase
Cerebral Stroke
Behavioral: Reaching Task
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Facilitating Implicit Learning to Improve Neurorehabilitation in Stroke

Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Motor Performance [ Time Frame: 2 Years ] [ Designated as safety issue: No ]
    Quality of motor behavior

Secondary Outcome Measures:
  • EEG derived event related potential [ Time Frame: 2 Years ] [ Designated as safety issue: No ]
    Brain electrophysiology measure of attentional processes

Estimated Enrollment: 30
Study Start Date: October 2013
Estimated Study Completion Date: September 2015
Estimated Primary Completion Date: September 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Implicit Group
Receives little feedback about task performance during learning
Behavioral: Reaching Task
Learn a reaching task that requires coordination of the arm segments
Active Comparator: Control
Receives detailed feedback about task performance during learning
Behavioral: Reaching Task
Learn a reaching task that requires coordination of the arm segments

  Show Detailed Description


Ages Eligible for Study:   45 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Ischemic stroke greater than 3 months prior.
  • Between 45 and 80 years of age.
  • Residual hemiparetic upper extremity deficits.
  • Adequate language and neurocognitive function to participate in training (MMSE, CESD, aphasia screening).
  • Right hand dominant.
  • Upper Extremity Fugl-Meyer score of 25 or greater.

Exclusion Criteria:

  • History of cortical stroke.
  • No mobility of less affected arm.
  • Failure to meet the RRDC assessment clinic criteria for medical eligibility.
  • MMSE score less than 27.
  • CES-D score greater than 16.
  • Unable to pass a hearing test (i.e. must be able to hear sounds of 45 dB or less).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT02017574

United States, Maryland
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States, 21201
Sponsors and Collaborators
Principal Investigator: Jeremy C Rietschel, PhD MA BA Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
  More Information

No publications provided

Responsible Party: Department of Veterans Affairs Identifier: NCT02017574     History of Changes
Other Study ID Numbers: N0970-M
Study First Received: December 16, 2013
Last Updated: May 6, 2015
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Cerebral Infarction

Additional relevant MeSH terms:
Cerebral Infarction
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases processed this record on August 27, 2015